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FLASH GENE

Symbol

NDUFA10

contributors: mct - updated : 16-05-2013

HGNC name	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
HGNC id	7684

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	NDUFA10D NDUFA10 deficiency
Location	2q37.3      Physical location : 240.896.789 - 240.964.819
Synonym symbol(s)	CI-42KD, MGC5103, CI-42K
EC.number	1.6.99.3/ 1.6.5.3

DNA

TYPE	anonymous DNA segment
STRUCTURE	68.03 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004544 10 - - NP_004535 40.7 355 - 2010 18442173

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

complex I NDUFA10 subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	involved in the transfer of electrons from NADH to the respiratory chain
	is incorporated into complex I during the late assembly stages

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component alpha 10, hydrophobic fraction of the complex I, multisubunit enzyme of oxidative phosphorylation (OXPHOS), component of the hydrophobic protein fraction

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 FAD per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NDUFA10D

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene to screen for disease-causing mutations in patients with complex I deficiency
Marker
Therapy target

ANIMAL & CELL MODELS