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FLASH GENE
Symbol NDUFA10 contributors: mct - updated : 16-05-2013
HGNC name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
HGNC id 7684
Corresponding disease
NDUFA10D NDUFA10 deficiency
Location 2q37.3      Physical location : 240.896.789 - 240.964.819
Synonym symbol(s) CI-42KD, MGC5103, CI-42K
EC.number 1.6.99.3/ 1.6.5.3
DNA
TYPE anonymous DNA segment
STRUCTURE 68.03 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389089 2 LOC389089 NDUFA10 12p NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa LOC389090 2 similar to seven transmembrane helix receptor LOC391495 2 similar to DNA-directed RNA polymerase II largest subunit LOC150681 2q37.3 similar to Olfactory receptor 6B3 LOC391496 2 similar to olfactory receptor family 9 subfamily S LOC150678 2q37.3 helicase/primase complex protein LOC150677 LOC391497 2 similar to ENSANGP00000007346 GPC1 2q37.3 glypican 1 ANKMY1 2q37.3 ankyrin repeat and MYND domain containing 1 LOC285193 2q37.3 similar to RIKEN cDNA 0710001B24 RNPEPL1 2q37.3 arginyl aminopeptidase (aminopeptidase B)-like 1 CAPN10 2q37.3 calpain 10 GPR35 2q37.3 G protein-coupled receptor 35 LOC285192 2q37.3 similar to aquaporin 11 AQP12 2q37.3 aquaporin 12 ATSV 2q37.3 axonal transport of synaptic vesicles
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - - 40.7 355 - 2010 18442173
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY complex I NDUFA10 subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • involved in the transfer of electrons from NADH to the respiratory chain
  • is incorporated into complex I during the late assembly stages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component alpha 10, hydrophobic fraction of the complex I, multisubunit enzyme of oxidative phosphorylation (OXPHOS), component of the hydrophobic protein fraction
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 FAD per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFA10D
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene to screen for disease-causing mutations in patients with complex I deficiency
    Marker
    Therapy target
    ANIMAL & CELL MODELS