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FLASH GENE
Symbol NDST3 contributors: npt/ - updated : 06-04-2004
HGNC name N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
HGNC id 7682
Location 4q26      Physical location : 118.955.499 - 119.179.786
Synonym name
  • GlcNAc N-deacetylase/ N-sulfotransferase 3
  • bifunctional heparan sulfate
  • N-heparan sulfate sulfotransferase 3
  • Synonym symbol(s) HSST3, MGC130028, MGC130029, hNDST-3
    EC.number 2.8.2.8
    DNA
    TYPE functioning gene
    STRUCTURE 221.52 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC132391 4q26 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC344978 4q26 similar to actinin, alpha 4 MGC26568 NT5C3P1 4q26 5'-nucleotidase, cytosolic III pseudogene 1 NDST3 4q26 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 PRSS12 4q24-q25 protease, serine, 12 (neurotrypsin, motopsin) MGC26143 4q27 hypothetical protein MGC26143 LOC389220 4 LOC389220 LOC391690 4 similar to capicua homolog KIAA1627 4q27 KIAA1627 protein SEC24D 4q26 SEC24 related gene family, member D (S. cerevisiae) SYNPO2 4q26 synaptopodin 2 MYOZ2 4q26-q27 myozenin 2 MRPL42P1 4q27 myozenin 2 KIAA1350 FABP2 4q28-q31 fatty acid binding protein 2, intestinal LOC201989 4q27 similar to Glycerol kinase, testis specific 1 (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) LOC389221 4 similar to hypothetical protein LOC349114 LOC389222 4 LOC389222 LOC152972 4q27 similar to bA291L22.2 (similar to CDC10 (cell division cycle 10, S. cerevisiae, homolog)) PDE5A 4q26 phosphodiesterase 5A, cGMP-specific LOC391691 4 similar to ARHGAP20 protein MAD2L1 4q27 MAD2 mitotic arrest deficient-like 1 (yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5961 100.8 873 - Aikawa (1999)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Lymphoid/Immunethymus    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, brain, kidney, spleen, liver, lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Ndst3
    homolog to Drosophila sfl
    homolog to C.elegans hst1
    Homologene
    FAMILY
  • sulfotransferase 1 family
  • NDST subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • catalysing the N-deacylation and the N sulfate transfert in N-acetyl glucosamine subunits of heparan sulfate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • phosphoadenosyl phosphosulfate (PAPS), N acetyl glucosamine in proteoglycans
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS