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FLASH GENE
Symbol NDST2 contributors: npt - updated : 17-08-2007
HGNC name N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
HGNC id 7681
Location 10q22      Physical location : 75.561.668 - 75.571.589
Synonym name
  • glucosaminyl N-deacetylase/N-sulfotransferase 2
  • N-heparan sulfate sulfotransferase 2
  • bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
  • Synonym symbol(s) HSST2, NST2, NCST2, MGC129697, MGC129705, NDST-2
    EC.number 2.8.2.8, 3.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.67 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3778 100.9 883 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ndst2
    homolog to Drosophila sfl
    homolog to C.elegans hst-1
    Homologene
    FAMILY
  • sulfotransferase 1 family
  • NDST subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • heparan sulfate-N-deacetylase/N-sulfotransferase 2
  • playing a role in heparan biosynthesis
  • catalysing the N-sulfatation and N-deacetylyation of glucosamine of the glycosaminoglycan in the heparin sulfate
  • playing a role in determining the extend of modification of the polysaccharide chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS