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FLASH GENE
Symbol NDRG4 contributors: mct - updated : 15-01-2010
HGNC name NDRG family member 4
HGNC id 14466
Location 16q21      Physical location : 58.497.548 - 58.547.522
Synonym name
  • smooth muscle-associated protein 8
  • brain development-related molecule 1
  • vascular smooth muscle cell-associated protein 8
  • Synonym symbol(s) KIAA1180, SMAP8, FLJ30586, FLJ42011, BDM1, DKFZp686I1615, MGC19632
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 49.97 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3160 37.08 339 only in brain (neurons of brain, spinal cord) 2001 11352569
    also called NDRG4B
    - splicing 3190 38.45 352 minor expression 2001 11352569
    also called NDRG4BV
    16 splicing 3356 40.64 371 both brain and heart 2009 19592488
    also called NDRG4H, isoform 1
    16 - 3581 - 391 - 2009 19592488
    also called variant 2
    16 - 3414 - 371 - -
    also called variant 3
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Nervousbrainhindbraincerebellum   Homo sapiens
     nerve   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    cell cycle     cell cycle
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus bdm1
    intraspecies homolog to NDRG1
    homolog to NDRG2 (60p1000)
    Homologene
    FAMILY N-Myc downstream-regulated gene (NDRG) family
    CATEGORY regulatory , signaling hormone
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be playing a role in the early postnatal development and function of neuronal cells
  • may play a role in supporting the activation of ERK and its target proteins needed for neuronal differentiation and in reducing the activation of ELK1 implicated in cell growth
  • essential role in regulating proliferation and growth of cardiomyocytes, suggesting that it may function downstream of TBX5 during heart development and growth
  • may play a partially redundant role in specific cells in the brain
  • required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and glioblastoma multiforme (GBM)cells
  • presence of NDRG4 is required for the viability of GBM cell populations and primary astrocytes and in GBM cells, required for continued progression through the cell cycle and ultimately for survival
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    glioblastoma multiforme (GBM) cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation and promoter methylation is a potential biomarker for the noninvasive detection of colorectal cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression