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FLASH GENE
Symbol NDRG3 contributors: npt/mct - updated : 08-07-2010
HGNC name NDRG family member 3
HGNC id 14462
Location 20q11.23      Physical location : 35.280.169 - 35.374.481
Synonym name N-myc downstream regulated gene 3
Synonym symbol(s) FLJ13556
DNA
TYPE functioning gene
STRUCTURE 94.31 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing 2928 - 363 - Kalaydjieva (2000)
16 splicing 2964 - 375 - Kalaydjieva (2000)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrineparathyroid   highly
Lymphoid/Immunethymus    
Nervousbrain   highly
Reproductivefemale systembreastmammary gland highly
 male systemtestis  highly
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacking the hydrophilic sequence of NDRG1
  • mono polymer octamer
    HOMOLOGY
    interspecies homolog to Ndr3
    intraspecies homolog to NDRG2
    homolog to NDRG1
    Homologene
    FAMILY
  • N-myc down-regulated gene (NDRG) family
  • CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text detected in the nuclei in most cells (Okuda 2008)
    basic FUNCTION
  • involved in cellular differentiation events
  • may play a partially redundant role in specific cells in the brain (Okuda 2008)
  • tumor promoter, and its overexpression may contribute to the malignant phenotype of tumors (Wang 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinomas (Wang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS