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FLASH GENE
Symbol NDRG2 contributors: mct/npt/pgu - updated : 21-09-2015
HGNC name NDRG family member 2
HGNC id 14460
Location 14q11.2      Physical location : 21.484.922 - 21.493.935
Synonym name
  • alpha beta hydrolase fold
  • N-myc downstream regulated gene 2
  • protein Syld709613
  • cytoplasmic protein Ndr1
  • Synonym symbol(s) KIAA1248, SYLD, FLJ25522, DKFZp781G1938
    DNA
    TYPE functioning gene
    STRUCTURE 9.01 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • microRNA-650 (miR-650) targets a homologous DNA region in the promoter region of the NDRG2 gene and represses its expression at the transcriptional level (
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 2142 40.8 371 - 2002 11936845
  • isoform a
  • 16 splicing 2100 39.1 357 - 2002 11936845
  • lacking an alternate in frame exon compared to variant 1
  • encoding isoform b
  • 15 splicing 2033 39.1 357 - 2002 11936845
  • differing in the 5'UTR and lacking an alternate in frame exon compared to variant 1
  • encoding isoform b
  • 16 splicing 2075 40.6 371 - 2002 11936845
  • differing in the 5'UTr compared to variant 1
  • 15 splicing 2010 39.1 357 - 2002 11936845
  • differing in the 5'UTR and lacking an alternate in frame exon compared to variant 1
  • encoding isoform b
  • 16 splicing 2052 40 371 - 2002 11936845
  • differing in the 5'UTR compared to variant 1
  • encoding isoform a
  • 17 splicing 2119 40 371 - 2002 11936845
  • differing in the 5'UTR compared to variant 1
  • encoding isoform a
  • 16 splicing 2077 39 357 - 2002 11936845
  • differing in the 5'UTR and lacking an alternate in frame exon compared to variant 1
  • encoding isoform b
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly
     salivary gland   highly
    Nervousbrainbasal nucleicorpus callosum predominantly
     braindiencephalonthalamus predominantly
     brain   highly
     spinal cord   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte
    Nervousglia
    Nervousoligodendrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lacking the hydrophilic sequence of NDRG1
  • a central alpha-beta-hydrolase fold domain
  • several phosphorylation sites (its phosphorylation is mediated through insulin-stimulated AKT activation)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ndrg2 (95.5pc)
    homolog to rattus Ndrg2 (95.8pc)
    intraspecies homolog to NDRG1
    homolog to NDRG4 (60p1000)
    Homologene
    FAMILY
  • N-myc downregulated gene (NDRG) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in neurite outgrowth
  • may be a tumor suppressor gene
  • implicated in cell growth, differentiation, and apoptosis and is rapidly responsive to mineral corticoid-stimulation in the kidney
  • inhibiting JAK2 or STAT3 activation in a MAPK14 dependent manner and up-regulating the expression level of SOCS1 mRNA and protein
  • growth inhibitory gene in signal transduction pathway of breast cancer tumor cells
  • may play a partially redundant role in specific cells in the brain
  • possible role for NDRG2 in the intracellular signaling pathway mediated by modulation of the phosphorylation of the C-terminal amino acids
  • might have a pivotal role as one of intrinsic factors for the modulation of MAPK14 phosphorylation, and subsequently involve in controlling of IL10 production
  • candidate tumor-suppressor gene for oral squamous-cell carcinoma (OSCC) development and probably contributes to the tumorigenesis of OSCC partly via the modulation of Akt signaling
  • specifically expressed in dendritic cells (DC) differentiation and might have a biological role as an internal regulator for DC differentiation and function
  • its expression was negatively correlated with malignancy in hepatocellular carcinoma
  • exerted its anti-tumor activity by regulating CD24, a molecule that mediates cell-cell interaction, tumor proliferation and adhesion
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MCRS1
  • NDRG2 is a novel target for TRIM32 and TRIM32 is involved in control of myogenic cells proliferation and differentiation
  • regulation of GRIK2 by SGK1 and NDRG2 in astrocytes may play an important role in gliotransmission, modulation of gene expression and regulation of exocytosis of tissue-type plasminogen activator (tPA)
  • cell & other
    REGULATION
    inhibited by down-regulated by Myc through transcriptional repression on its core promoter region
    Other its expression is regulated by promoter methylation and miR-650 in colorectal cancer cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    by hypermethylation of the promoter in grade III meningioma
    tumoral     --low  
    in liver and pancreatic cancers
    tumoral     --low  
    in glioblastoma, lung and breast cancer, and clinically aggressive meningioma
    constitutional     --over  
    in Alzheimer disease
    tumoral     --over  
    overexpression inhibits glioblastoma (GBM) cell proliferation, and decreased NDRG2 expression correlates with decreased GBM patient survival
    tumoral     --low  
    dependent on promoter methylation, was seen in the majority of oral squamous-cell carcinoma cases and in several cases of precancerous leukoplakia with dysplasia
    tumoral     --low  
    in colorectal cancer compared to benign colorectal tissues, and hypermethylation of NDRG2 was significantly correlated with nodal metastasis and poor differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • biomarker to predict aggressive behavior in patients with meningioma
  • aberrant hypermethylation of the NDRG2 gene could be a molecular marker for detection and treatment of human colorectal cancers
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    potential target for therapeutic intervention in oral squamous-cell carcinoma
    ANIMAL & CELL MODELS
    Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression