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FLASH GENE
Symbol NDNL2 contributors: - updated : 23-08-2007
HGNC name necdin-like 2
HGNC id 7677
Location 15q11-q13      Physical location : 29.560.358 - 29.562.017
Synonym name
  • hepatocellular carcinoma-associated protein 4
  • MAGE-G1 antigen
  • hepatocellular carcinoma-associated protein HCA4
  • melanoma-associated antigen G1
    • Synonym symbol(s) HCA4, MAGEG1, MAGEL3
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GABRA5 15q11.2-q12 gamma-aminobutyric acid (GABA) A receptor, alpha 5 LOC390550 15 LOC390550 GABRG3 15q11.2-q12 gamma-aminobutyric acid (GABA) A receptor, gamma 3 OCA2 15q11.2-q12 oculocutaneous albinism II (pink-eye dilution homolog, mouse) LOC388091 15 LOC388091 HERC2 15q13 hect domain and RLD 2 RPL41P2 15q11-q13 ribosomal protein L41, pseudogene 2 LOC390551 15 similar to hect domain and RLD 2 LOC390552 15 similar to hypothetical protein FLJ36144 LOC388092 15 similar to hypothetical protein LOC342156 15q12 similar to ATP-binding cassette, sub-family B, member 10, mitochondrial precursor (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2) LOC388093 15 similar to hypothetical protein MGC5244 LOC390553 15 hypothetical gene supported by NM_012089 LOC388094 15 similar to hypothetical protein LOC390554 15 similar to hypothetical protein FLJ36144 LOC388095 15 hypothetical gene supported by NM_004667 LOC342179 15q12 similar to KIAA0855 protein LOC390555 15 similar to Mothers against decapentaplegic homolog interacting protein (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP) LOC388096 15 LOC388096 LOC219392 15q12 similar to HP95 APBA2 15q14 amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) NDNL2 15q11-q13 necdin-like 2 LOC390556 15 similar to tubulin, beta 5 LOC283697 15q13.1 hypothetical protein LOC283697 TJP1 15q13 tight junction protein 1 (zona occludens 1) LOC390557 15 similar to chromosome condensation protein G LOC283698 15q13.1 similar to synaptogyrin 2; cellugyrin LOC283717 15q13.1 similar to hypothetical protein FLJ35785 LOC390558 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC388097 15 similar to hyperpolarization activated cyclic nucleotide-gated potassium channel 2; brain cyclic nucleotide gated channel 2 CHRFAM7A 15q13-q14 CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion LOC390559 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC388098 15 similar to hypothetical protein FLJ35785 LOC388099 15 similar to M-phase phosphoprotein 10 LOC342167 15q13.1 similar to hypothetical protein FLJ35785 LOC390560 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC388100 15 hypothetical gene supported by AF029838; NM_139320 LOC388101 15 hypothetical gene supported by NM_173613 LOC388102 15 hypothetical gene supported by NM_014783 LOC390561 15 similar to hypothetical protein FLJ35785 LOC388103 15 hypothetical gene supported by NM_004667 LOC388104 15 similar to chromosome 1 open reading frame 37 KIAA1018 15q12 similar to chromosome 1 open reading frame 37 FLJ20313 15q13.1 hypothetical protein FLJ20313 TRPM1 15q13-q14 transient receptor potential cation channel, subfamily M, member 1 LOC283710 15q13.1 hypothetical LOC283710 KLF13 15q13.3-q14 Kruppel-like factor 13 LOC283711 15q13.1 hypothetical protein LOC283711 LOC388105 15 hypothetical gene supported by BC009274; NM_020385 C15orf16 15q13.1 chromosome 15 open reading frame 16
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   highly
     parathyroid   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING paternally
    text likely maternally expressed like the neighbour UBE3A gene
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a MAGE domain
    HOMOLOGY
    interspecies ortholog to 76p100 identical to the murine Mage-g1 protein
    intraspecies homolog to NDN
    Homologene
    FAMILY necdin/MAGE gene family
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION growth suppressor that facilitates the entry of the cell into cell cycle arrest
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds the C-terminus of E2F1 and NGFR
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS