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FLASH GENE
Symbol NDFIP2 contributors: mct/pgu - updated : 24-09-2018
HGNC name Nedd4 family interacting protein 2
HGNC id 18537
Location 13q31.1      Physical location : 80.055.258 - 80.130.205
Synonym name
  • MAPK-activating protein PM04 PM05 PM06 PM07
  • NEDD4 WW domain-binding protein 5A
  • NF-kappa-B-activating protein 413
  • Synonym symbol(s) KIAA1165, N4wbp5a, FLJ25842
    DNA
    TYPE functioning gene
    STRUCTURE 72.94 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4606 - 316 - PMID: 15252135
    8 - 4666 - 336 - PMID: 15252135
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineplacenta    
    Respiratoryrespiratory tracttrachea   
    Skin/Tegumentskin   highly
    Urinarybladder   highly
     kidneytubulecollecting duct highly
     kidneynephron  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two PY motifs, PPxY motifs mediating interaction with WW domains of NEDD4 , PY motifs by which they bind NEDD4 family members and bring them close to target proteins
  • three putative transmembrane domains
  • HOMOLOGY
    interspecies homolog to murine Ndfip2
    Homologene
    FAMILY
  • NEDD4-binding protein family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text predominantly a golgi-associated protein, localized to the Golgi, vesicles associated with the Golgi complex and to multivesicular bodies
    basic FUNCTION
  • a role in positive regulation of I-kappa B kinase/NF-kappa B cascade
  • a potential role in regulation of epithelial sodium channel, enhancing its surface expression
  • regulates NEDD4 availability and trafficking
  • may play a regulatory role in modulating NEDD4 activity at the level of the Golgi apparatus in T lymphocytes
  • IL4 regulated genes, that promotes IFN-gamma production by the polarized human Th1 lymphocytes
  • activate the catalytic activity of ITCH and of several other HECT ligases by binding to them
  • role in protein trafficking and acts as an adaptor to recruit NEDD4 family ubiquitin-protein ligases to the protein trafficking machinery
  • may inhibit the NEDD4-dependent ubiquitylation of membrane proteins containing PY motifs, such as GJA1, in a competitive manner
  • promote ubiquitination both of Jun proteins, which have a PY motif, and of endophilin, which does not
  • related endosomal membrane proteins that bind to and activate members of the NEDD4 family of E3 ubiquitin ligases
  • NDFIP1/NDFIP2 regulate the cross talk between the T-cell receptor and cytokine signalling pathways to limit inappropriate T-cell responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component important component of the signaling machinery, with the ability to modulate the relative activities of different pathways emanating from a single growth factor
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to NEDD4
  • can physically interact with the WW domains of several NEDD4-family proteins
  • physically and functionally associated with multiple components of the EGF signaling cascade, and their levels modulate the relative output of different signaling pathways
  • NDFIP2 is a potential regulator of the iron transporter SLC11A2 in the liver
  • cell & other
    REGULATION
    inhibited by cyclosporine
    Other up-regulated following T cell activation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ndfip2(-/-) female mice showed an increase in Slc11a2 expression in the liver, with no change in male mice