SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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text
| predominantly a golgi-associated protein, localized to the Golgi, vesicles associated with the Golgi complex and to multivesicular bodies |
basic FUNCTION
| a role in positive regulation of I-kappa B kinase/NF-kappa B cascade |
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a potential role in regulation of epithelial sodium channel, enhancing its surface expression |
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regulates NEDD4 availability and trafficking |
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may play a regulatory role in modulating NEDD4 activity at the level of the Golgi apparatus in T lymphocytes |
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IL4 regulated genes, that promotes IFN-gamma production by the polarized human Th1 lymphocytes |
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activate the catalytic activity of ITCH and of several other HECT ligases by binding to them |
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role in protein trafficking and acts as an adaptor to recruit NEDD4 family ubiquitin-protein ligases to the protein trafficking machinery |
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may inhibit the NEDD4-dependent ubiquitylation of membrane proteins containing PY motifs, such as GJA1, in a competitive manner |
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promote ubiquitination both of Jun proteins, which have a PY motif, and of endophilin, which does not |
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related endosomal membrane proteins that bind to and activate members of the NEDD4 family of E3 ubiquitin ligases |
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NDFIP1/NDFIP2 regulate the cross talk between the T-cell receptor and cytokine signalling pathways to limit inappropriate T-cell responses |