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FLASH GENE
Symbol NDFIP2 contributors: mct/pgu - updated : 23-09-2010
HGNC name Nedd4 family interacting protein 2
HGNC id 18537
Location 13q31.1      Physical location : 80.055.258 - 80.130.205
Synonym name
  • MAPK-activating protein PM04 PM05 PM06 PM07
  • NEDD4 WW domain-binding protein 5A
  • NF-kappa-B-activating protein 413
  • Synonym symbol(s) KIAA1165, N4wbp5a, FLJ25842
    DNA
    TYPE functioning gene
    STRUCTURE 72.94 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC122145 13q21.33 suppressor of bimD6 homolog pseudogene LOC387936 13 hypothetical gene supported by AL133018 LOC387937 13 LOC387937 TBC1D4 13q22 TBC1 domain family, member 4 AK000009  Acrg embryonic lethality (mouse) minimal region ortholog UCHL3 13q22 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) LMO7 13q22 LIM domain only 7 KCTD12 13q21 potassium channel tetramerisation domain containing 12 BTF3L1 13q22 basic transcription factor 3, like 1 LOC341720 13q22.1 similar to immune-responsive gene 1 LOC390413 13 similar to 60S ribosomal protein L7 DHX9P 13q21 DEAH (Asp-Glu-Ala-His) box polypeptide 9 pseudogene CLN5 13q22 ceroid-lipofuscinosis, neuronal 5 FBXL3A 13q22 F-box and leucine-rich repeat protein 3A PAM 5q15 peptidylglycine alpha-amidating monooxygenase SCEL 13q22 sciellin LOC390414 13 similar to chromosome 15 open reading frame 2 FLJ30046 13q22.1 hypothetical protein FLJ30046 EDNRB 13q22 endothelin receptor type B POU4F1 13q21.1-q22 POU domain, class 4, transcription factor 1 C13orf7 13q22.2 chromosome 13 open reading frame 7 LOC341732 13q22.2 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) LOC390415 13 similar to T-complex protein 1, epsilon subunit (TCP-1-epsilon) (CCT-epsilon) C13orf10 13q22.1 chromosome 13 open reading frame 10 NDFIP2 13q22.1 Nedd4 family interacting protein 2 SPRY2 13q31-q32 sprouty homolog 2 (Drosophila) LOC150928 13q22.3 hypothetical LOC150928 SLITRK1 13q31.1 SLIT and NTRK-like family, member 1 VENTX2P2 13q31.1 VENT-like homeobox 2 pseudogene 2 LOC387939 13 LOC387939
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4606 - 316 - PMID: 15252135
    8 - 4666 - 336 - PMID: 15252135
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineplacenta    
    Respiratoryrespiratory tracttrachea   
    Skin/Tegumentskin   highly
    Urinarybladder   highly
     kidneytubulecollecting duct highly
     kidneynephron  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two PY motifs, PPxY motifs mediating interaction with WW domains of NEDD4
  • three putative transmembrane domains
  • HOMOLOGY
    interspecies homolog to murine Ndfip2
    Homologene
    FAMILY
  • NEDD4-binding protein family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text predominantly a golgi-associated protein, localized to the Golgi, vesicles associated with the Golgi complex and to multivesicular bodies
    basic FUNCTION
  • a role in positive regulation of I-kappa B kinase/NF-kappa B cascade
  • a potential role in regulation of epithelial sodium channel, enhancing its surface expression
  • regulates NEDD4 availability and trafficking
  • may play a regulatory role in modulating NEDD4 activity at the level of the Golgi apparatus in T lymphocytes
  • IL4 regulated genes, that promotes IFN-gamma production by the polarized human Th1 lymphocytes
  • activate the catalytic activity of ITCH and of several other HECT ligases by binding to them
  • role in protein trafficking and acts as an adaptor to recruit NEDD4 family ubiquitin-protein ligases to the protein trafficking machinery
  • may inhibit the NEDD4-dependent ubiquitylation of membrane proteins containing PY motifs, such as GJA1, in a competitive manner
  • promote ubiquitination both of Jun proteins, which have a PY motif, and of endophilin, which does not
  • related endosomal membrane proteins that bind to and activate members of the NEDD4 family of E3 ubiquitin ligases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component important component of the signaling machinery, with the ability to modulate the relative activities of different pathways emanating from a single growth factor
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to NEDD4
  • can physically interact with the WW domains of several NEDD4-family proteins
  • physically and functionally associated with multiple components of the EGF signaling cascade, and their levels modulate the relative output of different signaling pathways
  • cell & other
    REGULATION
    inhibited by cyclosporine
    Other up-regulated following T cell activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS