Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NDE1 contributors: mct/pgu - updated : 12-03-2015
HGNC name nudE nuclear distribution gene E homolog 1 (A. nidulans)
HGNC id 17619
Corresponding disease
EMCLIS extreme microcephaly with lissencephaly
Location 16p13.11      Physical location : 15.737.123 - 15.820.206
Synonym name
  • LIS1-interacting protein NUDE1 (nuclear distribution), rat homolog
  • nuclear distribution gene E homolog 1
  • Synonym symbol(s) NUDE, NUDE1, FLJ20101, HOM-TES-87
    DNA
    TYPE functioning gene
    STRUCTURE 83.09 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390675 16 similar to TATA element modulatory factor 1 ERCC4 16p13.13 excision repair cross-complementing rodent repair deficiency, complementation group 4 MRTF-B 16p13.13 myocardin-related transcription factor B CGI-148P 16p13 CGI-148 protein pseudogene LOC388214 16 LOC388214 PARN 16p13 poly(A)-specific ribonuclease (deadenylation nuclease) BFAR 16p13.2 bifunctional apoptosis regulator PLA2G10 16p13.1-p12 phospholipase A2, group X PKD1P3 16p13.3 phospholipase A2, group X NPIP 16q13.1 nuclear pore complex interacting protein LOC123803 RRN3 16p12 RNA polymerase I transcription factor RRN3 PKD1P6 16p13.3 RNA polymerase I transcription factor RRN3 LOC388215 16 similar to hypothetical protein LOC339047 FLJ39599 16p13.13 hypothetical protein FLJ39599 BC008967 16p13.13 hypothetical gene BC008967 LOC388216 16 LOC388216 LKAP 16p13.13 limkain b1 NDE1 16p13.11 nudE nuclear distribution gene E homolog 1 (A. nidulans) MYH11 16p13.12 myosin, heavy polypeptide 11, smooth muscle FLJ31153 16p13.13-p13.12 hypothetical protein FLJ31153 LOC390676 16 similar to 60S ribosomal protein L15 ABCC1 16p13.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC6 16p13.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 LOC339041 16p13.12 hypothetical LOC339041 PKD1P1 16p13.3 hypothetical LOC339041 PKD1P2 16p13.3 hypothetical LOC339041 LOC390677 16 similar to hypothetical protein FLJ21415 XYLT1 16p13.1-p12 xylosyltransferase I LOC146110 16p13.12 similar to 60S ribosomal protein L7 LOC390678 16 similar to Group X secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GX) (GX sPLA2) (sPLA2-X)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3936 - 335 - 2002 12032826
    9 - 3222 - 335 - 2002 12032826
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Reproductivefemale systemovary  highly
     female systembreastmammary gland highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region forms a coiled-coil structure, which is involved in homodimerisation
  • six putative CDC2 phosphorylation sites
  • an additional helical region near the C-terminus (amino acids 247278), and C-terminal domain, required for interaction
  • with key protein partners dynein and DISC1 (disrupted-in-schizophrenia 1), includes a predicted disordered region that allows a bent back structure
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Nde1 (84.2pc)
    ortholog to murine Nde1
    intraspecies paralog to NDEL1
    Homologene
    FAMILY
  • nuclear distribution (NudE) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes to the interphase centrosome and to
  • the mitotic spindle
  • associated to the centrosome (connected to its role in neuronal migration, since the centrosome is believed to aid nuclear movement (nucleokinesis) as neurons move to its final destination in the cortex)
  • basic FUNCTION
  • acting as regulator of cytoplasmic dynein in poleward protein transport along the mitotic spindle
  • required for centrosome duplication and formation and function of the mitotic spindle
  • may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors
  • can form a protein complex with ZNF365 in the centrosome and plays an important role for successful mitosis
  • abrogates alone dynein force production whereas it induces persistent-force dynein state with PAFAH1B1 and thus is required in the transport of nuclei, centrosomes, chromosomes and the microtubule cytoskeleton
  • essential for the development of the cerebral cortex
  • acting upstream of PAFAH1B1 in dynein recruitment and/or activation on the membrane
  • NDE1 and DCTN1 are likely associated with distinct dynein pools having specific functions
  • NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment
  • NDE1 forms needle-like dimers and tetramers in solution, similar to crystal structures of NDEL1, as well as chain-like end-to-end polymers
  • NDEL/NDE1 and PAFAH1B1 promote dynein and dynactin interaction in the context of spindle morphogenesis
  • NDE1, NDEL1 are essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders
  • NDE1-mediated heterochromatin replication is indispensible for neuronal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • interacting with other centrosome components as part of a multiprotein complex that regulates dynein function
  • molecular complex composed of NDE1, PAFAH1B1, and BRAP regulates the dynamic MAPK signaling threshold in a spatially dependent fashion
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stably recruits PAFAH1B1 to the dynein holoenzyme molecule, not competitively with PAFAH catalytic subunit
  • bind to the DISC1 protein
  • interacting with ZNF365
  • substrate of PKA (protein kinase A, a cAMP-dependant kinase)(potential link between PDE4A and the LIS1/NDE1/NDEL1 complex)
  • major function of CENPF, is to link the NDEL1/NDE1/PAFAH1B1/Dynein pathway to kinetochores (NDEL1 and NDE1 play distinct roles to ensure chromosome alignment and segregation)
  • interacting with CEP110, dynein, SLMAP, TCP1, CENPF, dynactin, tubulin gamma, PCM1, PCNT
  • cell & other
    REGULATION
    Other phosphoryalted in mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s) EMCLIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    may lead to genomic neurological disorders
    Susceptibility to schizophrenia in interaction with its partners DISC1 and NDEL1
    Variant & Polymorphism SNP
  • increasing the risk of schizophrenia in females
  • Candidate gene for autism/MR in a recurrent 1.5Mb duplication/deletion
    Marker
    Therapy target
    ANIMAL & CELL MODELS