SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,lysosome
|
text
| colocalizing with presenilin |
basic FUNCTION
| modulating presenilin mediated notch/glp-1 signal transduction in C elegans |
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potential modulator of APP beta cleavage by secretase gamma |
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involved in the degradation of amyloid precursor protein to produce beta-amyloid peptides |
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member of the gamma-secretase complex, playing a role, with PSEN1, APH1A, PSENEN, necessary and sufficient to reconstitute gamma-secretase activity |
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essential component of the gamma secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteolytic cleavage |
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can function to maintain epithelial to mesenchymal transition during breast cancer progression |
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part of the gamma-secretase complex and potentially involved in substrate recognition and selection |
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regulates EMT and breast cancer stem cells through NOTCH and AKT1 pathways |