basic FUNCTION
| regulator of g-protein coupled receptor phosphorylation in a calcium dependent manner |
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involved in the regulation of dense-core granule exocytosis |
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may be involved in a variety of brain function such a sensory processing, motor control, emotional control, learning and memory |
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can substitute for calmodulin |
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involved in in the regulation of ERK1/2 signaling and inflammatory reactions in mast cells, with PI4KB |
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plays an important role in neurotransmitter release and interacts with a plethora of binding partners mostly through a large solvent-exposed hydrophobic crevice |
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has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins |
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Ca2+-binding protein, having an important role in cardiac survival during stress |
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contributes to stress tolerance in cardiomyocytes at least in part by activating certain Ca2+-dependent survival pathways that promote mitochondrial biosynthesis/function and detoxification pathways |
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multi-functional Ca2+-binding protein that affects a range of cellular processes beyond those related to neurons |
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plays a role in the aggressive behavior of a subset of breast cancer |
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in WFS1-deficient cells, NCS1 overexpression not only restored ER-mitochondria interactions and Ca2+ transfer but also rescued mitochondrial dysfunction |
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key role of NCS1 in ER-mitochondria cross-talk |
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regulates many vital processes such as synaptic transmission |