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FLASH GENE
Symbol NCR2 contributors: mct - updated : 09-03-2012
HGNC name natural cytotoxicity triggering receptor 2
HGNC id 6732
Location 6p21.1      Physical location : 41.303.527 - 41.318.625
Synonym name
  • lymphocyte antigen 95 (activating NK-receptor ; NK-p44)
  • NK cell activating receptor (NKp44)
  • CD336 antigen
    • Synonym symbol(s) NKP44, NK-P44, LY95, CD336, dJ149M18.1
    DNA
    TYPE functioning gene
    STRUCTURE 15.10 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 941 30.7 276 - 1999 10049942
    IL2 activated NK cells
    - - 3700 - - - 1999 10049942
    IL2 activated NK cells
    6 - 1084 - 270 - 1999 10049942
    6 - 1048 - 258 - 1999 10049942
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node     Homo sapiens
     tonsils     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single extracellular V-type domain
  • a single transmembrane segment
  • potential N and O linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila Cg7564
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • natural cytotoxicity receptor (NCR) family
    • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • major activating receptor involved in the recognition and lysis of tumor cells
  • IL3-mediated induction of NCR2 on IPCs (interferon-producing cells) may be an important component of the ongoing crosstalk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus
  • playing a role in natural killer cell activation
  • NCR1, NCR2, NCR3 are thought to be NK lineage restricted
  • mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells
  • with NCR1 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TYROBP
  • LAIR1, highly expressed by plasmacytoid dendritic cells, acts complementary with NCR2 to control IFNA production
  • interaction with PCNA inhibits NK cell function through NCR2/ITIM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS