basic FUNCTION
| major activating receptor involved in the recognition and lysis of tumor cells |
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having a role in NK cell activation |
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involved in NK cell activation mediated by non-HLA class I ligands |
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critical and differential roles of NCR1- and NCR3-activating receptors expressed by uterine NK cells in early pregnancy |
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NCR1, NCR2, NCR3 are thought to be NK lineage restricted |
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with NCR2 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands |
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essential for the development of type 1 diabetes and is a potential new therapeutic modalities for this disease |
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specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands |
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major killer receptor expressed by NK cells, recognizing an unknown ligand expressed by pancreatic beta cells and in the absence of NCR1, or when its activity is blocked, diabetes development is inhibited |
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cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL22 |
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critical for the subsequent development of antiviral and antibacterial T cell responses, suggesting that the regulation of NK cell function by NCR1 allows for the optimal development of adaptive immune responses |