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FLASH GENE
Symbol NCR1 contributors: mct - updated : 09-03-2012
HGNC name natural cytotoxicity triggering receptor 1
HGNC id 6731
Location 19q13.42      Physical location : 55.417.507 - 55.424.439
Synonym name
  • lymphocyte antigen 94 homolog, activating NK-receptor
  • natural killer cell p46-related protein
  • Synonym symbol(s) LY94, NK-p46, NKP46, CD335
    DNA
    TYPE functioning gene
    STRUCTURE 6.93 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LILRB4 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 ILT9 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member6, pseudogene ILT10 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR3DL7 19q13.42 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR2DL3 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 LOC390973 19 similar to killer-cell Ig-like receptor KIR3DL7 KIR2DL1 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 LOC390974 19 similar to 1060P11.3 (killer inhibitory receptor 2-2-2 (KIR222) (KIRX)) LOC388562 19 similar to 1060P11.4.2 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (isoform 2) (KIR103-AS)) KIR3DL1 19q13.4 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 KIR2DS4 19q13.4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 FCAR 19q13.4 Fc fragment of IgA, receptor for NCR1 19q13.42 natural cytotoxicity triggering receptor 1 NALP7 19q13.42 NACHT, leucine rich repeat and PYD containing 7 NALP2 19q13.42 NACHT, leucine rich repeat and PYD containing 7 GP6 19q13.4 glycoprotein VI (platelet) RDH13 19q13.42 retinol dehydrogenase 13 (all-trans and 9-cis) EPS8L1 19q13.42 EPS8-like 1 PPP1R12C 19q13.42 protein phosphatase 1, regulatory (inhibitor) subunit 12C TNNT1 19q13.4 troponin T1, skeletal, slow
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1153 34.5 304 - 1998 9730896
    7 - 1150 32.6 303 - 1998 9730896
    6 - 1102 - 287 - 1998 9730896
    6 - 748 23.6 209 - 1998 9730896
    5 - 817 21.6 192 - 1998 9730896
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte Homo sapiens
    Lymphoid/Immunenatural killer Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two C2-type Ig-like extracellular domains, assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs)
  • a transmembrane domain associating with CD3Z
  • a cytoplasmic tail without the immunoreceptor tyrosine based activation motif (ITAM)
  • HOMOLOGY
    interspecies homolog to murine Ly94
    homolog to Drosophila cg7565
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • major activating receptor involved in the recognition and lysis of tumor cells
  • having a role in NK cell activation
  • involved in NK cell activation mediated by non-HLA class I ligands
  • critical and differential roles of NCR1- and NCR3-activating receptors expressed by uterine NK cells in early pregnancy
  • NCR1, NCR2, NCR3 are thought to be NK lineage restricted
  • with NCR2 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
  • essential for the development of type 1 diabetes and is a potential new therapeutic modalities for this disease
  • specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands
  • major killer receptor expressed by NK cells, recognizing an unknown ligand expressed by pancreatic beta cells and in the absence of NCR1, or when its activity is blocked, diabetes development is inhibited
  • cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL22
  • critical for the subsequent development of antiviral and antibacterial T cell responses, suggesting that the regulation of NK cell function by NCR1 allows for the optimal development of adaptive immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular defense response/killer activity
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could represent an additional marker on the circulating malignant T lymphocytes of SÚzary patients
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 1 
    new therapeutic target for type 1 diabetes
    ANIMAL & CELL MODELS
  • NKp46-deficient mice had less development of type 1 diabetes induced by injection of a low dose of streptozotocin