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FLASH GENE
Symbol NCOA7 contributors: mct/pgu - updated : 07-08-2008
HGNC name nuclear receptor coactivator 7
HGNC id 21081
Location 6q22.31      Physical location : 126.112.000 - 126.252.266
Synonym name
  • estrogen receptor associated protein 140 kDa
  • estrogen nuclear receptor coactivator 1
  • Synonym symbol(s) ERAP140, dJ187J11.3, ESNA1, FLJ45605, MGC88425, Nbla00052, Nbla10993
    DNA
    TYPE functioning gene
    STRUCTURE 150.87 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    C6orf170 6q22.32 chromosome 6 open reading frame 170 GJA1 6q22.3 gap junction protein, alpha 1, 43kDa (connexin 43) LOC260339 6q22.32 processed pseudogene mtTFA 3 LOC391966 6 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) LOC391967 6 similar to 60S ribosomal protein L23a HSF2 6q22.33 heat shock transcription factor 2 TDE2 6q22.32 tumor differentially expressed 2 PKIB 6q22.32 protein kinase (cAMP-dependent, catalytic) inhibitor beta FABP7 6q22-q23 fatty acid binding protein 7, brain SMPDL3A 6q22.32 sphingomyelin phosphodiesterase, acid-like 3A C6orf213 6q22.32 chromosome 6 open reading frame 213 TRDN 6q22-q23 triadin TCBA1 6q21-q22 T-cell lymphoma breakpoint associated target 1 IBRDC1 6q22.33 IBR domain containing 1 TPD52L1 6q22-q23 tumor protein D52-like 1 C6orf74 6q13-q24.3 chromosome 6 open reading frame 74 LOC256096 6q22.33 hypothetical LOC256096 HEY2 6q22.2-q22.33 hairy/enhancer-of-split related with YRPW motif 2 NCOA7 6q22.33 nuclear receptor coactivator 7 HINT3 6q22.33 histidine triad nucleotide binding protein 3 C6orf75 6q11.1-q22.33 chromosome 6 open reading frame 75 LOC391968 6 similar to PPP1R14B protein LOC389426 6 LOC389426 LOC391969 6 similar to ribosomal protein S4, X-linked LOC389427 6 similar to MGC32805 protein THSD2 6q22.33 thrombospondin, type I, domain 2 RNF146 6q22.1-q22.33 ring finger protein 146 ECHDC1 6q22.33 enoyl Coenzyme A hydratase domain containing 1 LOC246737 6q23.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene LOC389428 6 similar to ribosomal protein L5; 60S ribosomal protein L5 KIAA0408 6q22.33 KIAA0408 LOC389429 6 similar to RIKEN cDNA 2310057J18 MRPS17P5 6q22.33 mitochondrial ribosomal protein S17 pseudogene 5 PTPRK 6q22.2-q22.3 protein tyrosine phosphatase, receptor type, K LOC391970 6 similar to eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) LAMA2 6q22-q23 laminin, alpha 2 (merosin, congenital muscular dystrophy) LOC338470 6q22-q23 mesoderm specific transcript homolog (mouse) pseudogene ARHGAP18 6q23.1 Rho GTPase activating protein 18 C6orf191 6q23.1 chromosome 6 open reading frame 191 L3MBTL3 6q23 l(3)mbt-like 3 (Drosophila) SAMD3 6q23.1 sterile alpha motif domain containing 3 KIAA1913 6q23.1 KIAA1913
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 5455 106 942 - 2002 11971969
    16 splicing 5422 104.8 931 - 2002 11971969
  • using an alternate in-frame splice site compared to variant 1
  • - - - - - restricted to the reproductive system organs, particularly the uterus and the ovary 2008 18299425
  • unlike NCOA7, possesses a unique and highly conserved exon at the 5prime end and encodes a protein with a unique N-terminal sequence
  • one identifiable domain, TLDc, which has recently been suggested to be involved in protection from oxidative DNA damage
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainlimbic systemhippocampus predominantly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a LysM repeat
  • a TLD domain
  • HOMOLOGY
    interspecies homolog to murine Ncoa7 (83 pc)
    intraspecies paralog to OXR1
    Homologene
    FAMILY
  • OXR1 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a coactivator of endogenous ER alpha target genes by binding to the promoter region after its recruitment by estrogen-bound ER alpha
  • enhancing the transcriptional activities of several nuclear receptors
  • involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA
  • like its homologue, OXR1, NCOA7 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance
  • plays an important role in the regulation of ATRA-mediated neuronal differentiation, and is a novel member of prognostic indicators for neuroblastoma
  • OXR1 and its close homolog NCOA7 are produced in many different forms either as a result of alternative splicing, or alternative transcription start sites
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ER alpha
  • interacting with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner
  • interacting with the heterodimer AHR- ARNT
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS