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FLASH GENE
Symbol NCOA6 contributors: mct/pgu - updated : 12-01-2017
HGNC name nuclear receptor coactivator 6
HGNC id 15936
Location 20q11.22      Physical location : 33.302.578 - 33.413.433
Synonym name
  • nuclear receptor coactivator RAP250
  • peroxisome proliferator-activated receptor interacting protein
  • activating signal cointegrator-2
  • PPAR-interacting protein
  • Synonym symbol(s) KIAA0181, RAP250, ASC2, PRIP, NRC, AIB3, ASC-2, TRBP
    DNA
    TYPE functioning gene
    STRUCTURE 110.88 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure GC-rich and TATA-less, and containing multiple Sp1 binding sites and a MYC binding site
    MAPPING cloned Y linked N status confirmed
    Physical map
    C20orf178 20q11.22 chromosome 20 open reading frame 178 TPM5P 20q11.2 tropomyosin 5, pseudogene RALY 20q11.21-q11.23 RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow) EIF2S2 20pter-q12 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa LOC391244 20 similar to ribosomal protein S2; 40S ribosomal protein S2 XPOTP1 20q11.21 exportin, tRNA (nuclear export receptor for tRNAs) pseudogene 1 ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae) NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming) GSS 20q11.21 glutathione synthetase MYH7B 20q11.21 myosin, heavy polypeptide 7B, cardiac muscle, beta TRPC4AP 20q11.23 transient receptor potential cation channel, subfamily C, member 4 associated protein C20orf31 20q11.23 chromosome 20 open reading frame 31 PROCR 20q11.21 protein C receptor, endothelial (EPCR) MMP24 20q11.2 matrix metalloproteinase 24 (membrane-inserted) ITGB4BP 20q11.2 integrin beta 4 binding protein C20orf128 20q11.21 chromosome 20 open reading frame 128 C20orf44 20q11.23 chromosome 20 open reading frame 44 GDF5 20q11.2 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) CEP2 20pter-q12 centrosomal protein 2 LOC343705 20q11.23 similar to beta-galactoside alpha-2,3-sialyltransferase C20orf173 20q11.22 chromosome 20 open reading frame 173 SDBCAG84 20pter-q12 serologically defined breast cancer antigen 84 FER1L4 20q11.21 fer-1-like 4 (C. elegans) RPL37P1 11q13 ribosomal protein L37 pseudogene 1
    RNA
    TRANSCRIPTS type messenger
    text an alternatively spliced exon 11b (E11b) (PMID: 2155241)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 7071 - 2063 - 2011 2155241
    12 - 4092 - 1070 - 2011 2155241
    - - 9304 - 2063 - 2011 2155241
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • N terminal acidic domain
  • two NR box domain with specific LXXLL sequence motif, a short hydrophobic domain that is sufficient for ligand-dependent interactions with nuclear receptors
  • two glutamine-rich domains
  • an intrinsic glutamine-rich activation domain
  • multiple functional modules including pleckstrin homology and C2 domains, inhibited exocytosis, probably via the binding to membrane phosphoinositides through the pleckstrin homology domain
  • C-terminal domain is required for the interaction with SMAD2, and SMAD3
  • HOMOLOGY
    Homologene
    FAMILY nuclear receptor coactivator family
    CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of PPARG and RXR alpha (potentiates the transcriptional activities)
  • playing a critical role as a coactivator of nuclear receptors
  • coactivator of the xenobiotic nuclear receptor NR1I3 and mediate the specific xenobiotic response by NR1I3
  • coactivator of multiple nuclear receptors and transcription factors
  • with MLL3, NCOA6 and MLL4 are recruited to FXR target genes in a ligand-dependent manner
  • co-activator for nuclear hormone receptors and certain other transcription factors
  • plays an important role in embryonic development, adipocyte differentiation, metabolism and breast carcinogenesis
  • controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components
  • has an inhibitory role in regulated exocytosis
  • is a transcriptional coactivator and crucial for insulin secretion and glucose metabolism in pancreatic beta-cells
  • NCOA6 stimulates insulin secretion likely, at least partially, by modulating NAMPT expression in pancreatic beta-cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • component of a steady-state complex (ASCOM) also containing retinoblastoma binding protein RBQ3, alpha/beta tubulins and a subset of trithorax group proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • thyroid hormone receptor binding
  • peroxisome proliferation-activated receptor interacting protein
  • CREBBP
  • interacting with ATF2 to induce target gene transcription during granulocytic differentiation
  • interacting with ZNF335
  • binds to many nuclear receptors in a ligand-dependent manner through its two LxxLL motifs
  • differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors
  • reported coactivator for ESR1, attenuates E(2) sensitivity to determine uterine receptivity to embryo implantation under normal physiological conditions
  • cell & other
    REGULATION
    activated by TGS1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast cancer
    constitutional       loss of function
    in Dilated cardiomyopathy (DCM) (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • PRIP-deficient mice showed increased serum gonadotropins, but decreased gonadal steroid hormones
  • Prip gene knock-out (KO) in mice increases bone formation and concomitantly decreases bone resorption, resulting in increased bone mineral density and trabecular bone volume