basic FUNCTION
| may play an essential role in oogenesis |
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may also associate with myosin regulatory complexes (in addition to the WAVE actin-regulatory complex), and may have additional functions in inhibiting myosin-based contraction at the leading edge of migrating cells |
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versatile NCKAP1L-containing complexes coordinate diverse regulatory signals at the leading edge of polarized neutrophils, including but not confined to those involving WASF2-dependent actin polymerization |
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essential for hematopoietic cell development, function, and homeostasis by controlling a distinct pathway leading to cytoskeletal reorganization |
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may potentially stimulate waves of actin nucleation at the leading edge of cells, which may drive cell polarization, morphogenesis, and migration during chemotaxis |