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FLASH GENE
Symbol NCK2 contributors: mct/pgu - updated : 05-04-2016
HGNC name NCK adaptor protein 2
HGNC id 7665
Location 2q12.2      Physical location : 106.361.519 - 106.510.730
Synonym name
  • SH2/SH3 adaptor protein NCK-beta
  • noncatalytic region of tyrosine kinase, beta
  • cytoplasmic protein NCK2
    • Synonym symbol(s) NCKB, GRB4, NCKbeta
    DNA
    TYPE functioning gene
    STRUCTURE 77.84 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2527 - 380 - 2007 17906149
    4 - 2326 - 380 - 2007 17906149
    3 - 1805 - 83 - 2007 17906149
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemplacenta  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three SH3 domains (signal transduction)
  • a unique SH2 domain wich recognizes a specific phosphotyrosine residue on RTKS or on substrates of RTKS like IRS1, lacking a catalytic domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • transduction adaptator protein 2
  • modulates translation and eIF2alpha signaling in response to ER stress
  • . plays a pivotal role in connecting and integrating signaling networks constituted by transmembrane receptors such as ephrinB and effectors critical for cytoskeletonal dynamics and remodeling
  • NCK1, NCK2 adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor
  • independent roles and mechanisms of action of NCK1 and NCK2 in dermal fibroblast migration, which is critical for wound healing
  • adaptor protein, involved in signaling pathways mediating proliferation, cytoskeleton organization and integrated stress response
  • effectively influences melanoma phenotype progression
  • NCK1 and NCK2 have non-redundant roles in human T cell activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGFR
  • PDGFR
  • WIPF2
  • interaction partner of the active form of NTRK2
  • connection between septins, SOCS7, NCK1/NCK2 signaling, and the DNA damage response
  • connect PDGF-BB signaling to the actin cytoskeleton and cell motility
  • interaction with SORBS1 (implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells)
  • SKAP2 interacted with the SH2 domain of non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) via its N-terminus
  • only NCK2 is required for the SLIT1-induced changes in cortical neuron morphology
  • PAK3 down-regulates synaptic transmission through its interaction with NCK2
  • PLCE1 regulates Rho GTPase activity and cell migration through interacting with NCK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS