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Symbol NCK1 contributors: mct - updated : 13-04-2017
HGNC name NCK adaptor protein 1
HGNC id 7664
Location 3q22.3      Physical location : 136.581.049 - 136.667.967
Synonym name
  • NCK tyrosine kinase
  • SH2/SH3 adaptor protein NCK-alpha
  • non-catalytic region of tyrosine kinase
  • Synonym symbol(s) NCKA, MGC12668, NCK
    TYPE functioning gene
    STRUCTURE 89.40 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    EPHB1 3q21-q23 EphB1 LOC391580 3 similar to Succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (Ip) (Iron-sulfur subunit of complex II) PPP2R3A 3q22.2-q protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha FLJ10546 3q22.2 hypothetical protein FLJ10546 LOC391581 3 similar to ribosomal protein L31 PCCB 3q21-q22 propionyl Coenzyme A carboxylase, beta polypeptide STAG1 3q22-q24 stromal antigen 1 MGC3295 3q22.3 hypothetical protein MGC3295 NCK1 3q21 NCK adaptor protein 1 MGC34923 3q22.3 hypothetical protein MGC34923 NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog CHR3SYT 3q22.3 chr3 synaptotagmin BITE 3q22-q23 p10-binding protein FAIM 3q23 Fas apoptotic inhibitory molecule LOC256374 3q22.3 similar to peptidylprolyl isomerase A PIK3CB 3q22-q23 phosphoinositide-3-kinase, catalytic, beta polypeptide LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1938 - 377 - 2016 26871637
    4 - 4455 - 377 - 2016 26871637
    4 - 4185 - 313 - 2016 26871637
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • three SH3 domains
  • a unique SH2 domain that recognizes a specific phosphotyrosine residue on RTKS or on substrates of RTKS like IRS1, lacking a catalytic domain
  • a previously unrecognized activation motif in a linker between the first two SH3 domains, and this linker sequence, reminiscent of bacterial virulence factors, di26554011)rectly engages the WASL GTPase binding domain (GBD) and competes with verprolin-homology, connector-helix, acidic motif (VCA) binding
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS
  • intracellular adaptor protein that is involved in actin polymerization
  • independent roles and mechanisms of action of NCK1 and NCK2 in dermal fibroblast migration, which is critical for wound healing
  • endogenous regulator of PKR and NCK1-PKR interaction could be a way to limit PKR activation
  • NCK1 is the regulator of RASA1 activity
  • proteasomal regulation is a key factor in the distinct and non-redundant effects of NCK1 on RHOA-mediated actin dynamics
  • NCK1 and NCK2 have non-redundant roles in human T cell activation
  • role for NCK1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex
  • crucial role for NCK1 as a master regulator within the endothelium to control actin cytoskeleton organization, vascular network remodeling, and endothelial-to-mesenchymal transition (EnMT) during cardiovascular development
  • regulates preosteoblastic/osteoblastic migration and bone mass
    signaling signal transduction
    LCP2/GRAP2/NCK1 adaptor protein pathway, implicated in regulation of the actin cytoskeleton by BCR-ABL kinase
    a component
  • FYB/NCK1 complex might provide a means to link integrin activation with the actin cytoskeleton
    small molecule
  • associates with BLNK, PCLG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion
  • strong binding of CD3epsilon to EPS8L1 and NCK1 SH3 domains
  • connection between septins, SOCS7, NCK1/NCK2 signaling, and the DNA damage response
  • in podocytes, links the slit-diaphragm protein nephrin to the actin cytoskeleton (interaction essential for nephrin-dependent reorganization of actin in podocyte injury)
  • connect PDGF-BB signaling to the actin cytoskeleton and cell motility
  • interaction with SORBS1 (implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells)
  • functional cooperation between NCK1 and FYB mediates LCP2/WAS interactions and actin rearrangement
  • directly binds and activates the GTPase-activating protein of RAS (RASA1), which is responsible for the down-regulation of RAS
  • NCK1 interacts with PTPN1 and the NCK1/PTPN1 complex inducibly associates with the IR for the attenuation of IR activation in mammalian cells
  • LRFN4 complexed with SFN and NCK1 to mediate elongation in monocytic cells via RAC-1-mediated actin cytoskeleton reorganization
  • NCK1 directly modulates NPHS1 phosphorylation through formation of a signaling complex with the Src family kinase FYN
  • NCK1 recruitment to the TCR required for ZAP70 activation during thymic development
  • WIPF1 acts as an essential link between NCK1 and WASL
  • adaptor function for NCK1 in recruiting PK3AP1 to sites of BCR signaling
  • ITSN1 is an important general regulator of CDC42-, NCK1- and WASL-dependent actin polymerisation
  • NCK1 recruitment to the TCR is fundamental to mount an efficient T cell response, and the NCK1-CD3E interaction may represent a target for pharmacological modulation of the immune response
  • NCK1-ELMO1 interaction promoting RAC1 activation and cell motility
  • interacts with PTPN1 and also regulates PTPN1 expression, playing a role in regulating the PI3K/AKT1 pathway
  • NCK1 was the most potent activator of WASL-driven actin assembly
  • NCK1 integrates NPHS1 with the Hippo kinase cascade through association with the adaptor protein WTIP
  • cell & other
    Other phosphorylated on ser and tyr residues
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    NCK1 silencing in pancreatic beta cells promotes EIF2AK3 activation and signaling to protect beta cells against pathological stresses
    Susceptibility to diabetic nephropathy (DN) in type 1 diabetes mellitus
    Variant & Polymorphism other variant increasing the risk of diabetic nephropathy (DN) in type 1 diabetes mellitus
    Candidate gene
    Therapy target