Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NCF2 | contributors: mct/npt/pgu - updated : 29-05-2010 |
HGNC name | neutrophil cytosolic factor 2 |
HGNC id | 7661 |
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Corresponding disease |
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Location | 1q25.3 Physical location : 183.524.697 - 183.560.056 | ||
Synonym name | |||
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Synonym symbol(s) | NOXA2, p67phox, P67-PHOX, FLJ93058 | ||
EC.number | 1.6.99.- |
DNA |
TYPE | functioning gene |
STRUCTURE | 35.35 kb 16 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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text | presence of four NCF2 5'-UTR mRNA variants (designated as NCF2 exon 1, intron 1a, intron 1b and intron 1c) |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
| blood | |
at STAGE |
physiological period | pregnancy |
Text | placenta |
PROTEIN |
PHYSICAL PROPERTIES | acid | |
STRUCTURE |
HOMOLOGY |
interspecies | ortholog to murine Ncf2 |
ortholog to rattus Ncf2_predicted |
Homologene |
FAMILY |
CATEGORY | enzyme , immunity/defense |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus,nucleolus | |
text | translocated to the plasma membrane after activation |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | inflammation , electron transport |
PATHWAY |
metabolism | other |
signaling |
superoxide metabolism |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
activated by | binding to CYBB activated by RAC1 |
ASSOCIATED DISORDERS |
corresponding disease(s) | GDCC2 |
related resource | NCF2base: Mutation registry for autosomal recessive chronic granulomatous disease (CGD), deficiency of p67phox |
Susceptibility | to systemic lupus erythematosus (SLE) |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |