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FLASH GENE
Symbol NCEH1 contributors: npt - updated : 02-02-2010
HGNC name neutral cholesterol ester hydrolase 1
HGNC id 29260
Location 3q26.31      Physical location : 172.348.435 - 172.429.008
Synonym name
  • neutral cholesterol ester hydrolase
  • arylacetamide deacetylase-like 1
  • Synonym symbol(s) KIAA1363, NCEH, AADACL1
    EC.number 3.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 80.57 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4294 48.93 440 - 2008 18782767
    4 - 4065 - 275 - -
    5 - 4284 - 275 - -
    5 - 4318 - 448 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Endocrineadrenal gland   highly Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region contains a stretch of 23 hydrophobic amino acids
  • a putative transmembrane domain
  • HOMOLOGY
    interspecies homolog to murine Nceh (87.5 p100)
    Homologene
    FAMILY
  • 'GDXG' lipolytic enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • responsible for a major part of nCEH (neutral cholesterol ester hydrolase) activity in macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS