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FLASH GENE
Symbol NCDN contributors: mct/npt - updated : 24-02-2010
HGNC name neurochondrin
HGNC id 17597
Location 1p34.3      Physical location : 36.023.392 - 36.032.378
Synonym name norbin
Synonym symbol(s) NCDN-1, NCDN-2, KIAA0607, NC
DNA
TYPE functioning gene
STRUCTURE 8.99 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence
text structure repetitive sequences in the 3-prime UTR
MAPPING cloned Y linked N status provisional
Physical map
LOC113444 1p34.3 hypothetical protein BC011880 SAPAP3 1p35.3-p34.1 SAP90/PSD-95-associated protein 3 LOC388617 1 LOC388617 MGC14276 1p34.3 hypothetical protein MGC14276 ZNF258 1p34.2 zinc finger protein 258 LOC388618 1 similar to RIKEN cDNA 9330177P20 FLJ23151 1p34.3 hypothetical protein FLJ23151 SFPQ 1pter-p32.3 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) ZNF262 1p34-p32 zinc finger protein 262 LOC388619 1 similar to ribosomal protein L5; 60S ribosomal protein L5 PKD1-like 1p34.2 polycystic kidney disease 1-like NCDN 1p34.3 neurochondrin MGC49007 PSMB2 1p34.2 proteasome (prosome, macropain) subunit, beta type, 2 FLJ38984 1p34.3 hypothetical protein FLJ38984 CLSPN 1p34.2 claspin homolog (Xenopus laevis) EIF2C4 1p34.3 eukaryotic translation initiation factor 2C, 4 EIF2C1 1p35-p34 eukaryotic translation initiation factor 2C, 1 EIF2C3 1p34.3 eukaryotic translation initiation factor 2C, 3 LOC388620 1 similar to implantation-associated protein TEKT2 1p35.3-p34.1 tektin 2 (testicular) ADPRHL2 1p34.3 ADP-ribosylhydrolase like 2 COL8A2 1p34.3-p32.3 collagen, type VIII, alpha 2 TRAPPC3 1p34.2 trafficking protein particle complex 3 FLJ10350 1p34.3 hypothetical protein FLJ10350 TRAP150 FLJ22938 1p34.3 hypothetical protein FLJ22938 FLJ10647 1p34.3 hypothetical protein FLJ10647 MGC4796 1p34.3 Ser/Thr-like kinase LSM10 1p34.3 U7 snRNP-specific Sm-like protein LSM10 NOR1 1p34.3 oxidored-nitro domain-containing protein MRPS15 1p35-p34.1 mitochondrial ribosomal protein S15 CSF3R 1p34.2-p34.1 colony stimulating factor 3 receptor (granulocyte)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 splicing 3446 78 729 - Mochizuki (1999), Dateki (2005)
also called NCDN1
7 splicing 3378 77 712 - Mochizuki (1999), Dateki (2005)
also called NCDN2
7 splicing 3718 75 729 - Dateki (2005), Mochizuki (1999)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbraindiencephalonhypothalamus lowly
 brainhindbrainmedulla oblongata highly
 brainhindbraincerebellumdentate nuclei 
 brainlimbic systemhippocampus  
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing olfactory bulb
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFC domain
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to rattus Ncdn
    homolog to murine Ncdn
    Homologene
    FAMILY
  • fibrillar collagen family
  • neurochondrin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • leucine-rich cytoplasmic protein, involved in dendrite outgrowth
  • may be playing a role in chondrocytes differentiation
  • playing an essential role in early embryogenesis
  • involved in neurite outgrowth, chondrocyte differentiation, and bone metabolism
  • specific function in the modulation of DIAPH1 activity
  • has an important role for survival in early developmental stages
  • negative regulator of Ca(2+)/calmodulin-dependent protein kinase II phosphorylation and essential for the spatial learning process but not for the differentiation or neurite outgrowth of the neuron (Dateki 2005)
  • neuron-specific protein, that might influence cell surface expression of GRM5, and important endogenous modulator of GRM5 (Wang 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a negative regulator of Ca(2+)/calmodulin-dependent protein kinase II phosphorylation (resulting in epileptic seizure)
  • DIAPH1 interacting protein (specifically binds to the formin homology 3 (FH3), but not to the FH1 or FH2 domain)
  • physically interacts with GRM5, increases the cell surface localization of the receptor, and positively regulates GRM5 signaling (Wang 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may provide a therapeutic target for schizophrenia (Wang 2009)
    ANIMAL & CELL MODELS
    Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia, as indexed by alterations both in sensorimotor gating and psychotomimetic-induced locomotor activity (Wang 2009)