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FLASH GENE
Symbol NCBP2 contributors: mct - updated : 29-01-2013
HGNC name nuclear cap binding protein subunit 2, 20kDa
HGNC id 7659
Location 3q29      Physical location : 196.662.272 - 196.669.464
Synonym name
  • cell proliferation-inducing gene 55 protein
  • NCBP interacting protein 1
  • Synonym symbol(s) NIP1, CBP20, CBC2, PIG55
    DNA
    TYPE functioning gene
    STRUCTURE 7.19 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PPP1R2 3q29 protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC391606 3 similar to ribosomal protein L24 LOC255812 3q29 hypothetical protein LOC255812 LOC389187 3 LOC389187 MUC20 3q29 mucin 20 MUC4 3q29 mucin 4, tracheobronchial LOC285253 3q29 similar to SPBPJ4664.02 ACK1 3q29 activated Cdc42-associated kinase 1 LOC391607 3 hypothetical gene supported by AJ271448; NM_174907 LOC375386 3q29 similar to Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (Fp) (Flavoprotein subunit of complex II) LOC391608 3 hypothetical gene supported by AJ271448; NM_174907 TFRC 3q29 transferrin receptor (p90, CD71) ZDHHC19 3q29 zinc finger, DHHC domain containing 19 OSTalpha 3q29 organic solute transporter alpha PCYT1A 3q21-q28 phosphate cytidylyltransferase 1, choline, alpha isoform MGC33212 3q29 hypothetical protein MGC33212 LOC116211 3q29 hypothetical protein BC013113 KIAA0794 3q29 hypothetical protein BC013113 LOC389188 3 LOC389188 FLJ35794 3q29 hypothetical protein FLJ35794 LOC255798 3q29 hypothetical protein LOC255798 MGC64882 3q29 hypothetical protein MGC64882 LOC200933 3q29 hypothetical protein LOC200933 LOC389189 3 LOC389189 UNQ3030 3q29 ELLP3030 MGC14126 3q29 hypothetical protein MGC14126 FLJ20522 3q29 hypothetical protein FLJ20522 PAK2 3q29 p21 (CDKN1A)-activated kinase 2 MGC27076 3q29 hypothetical protein MGC27076 NCBP2 3q29 nuclear cap binding protein subunit 2, 20kDa LOC152217 3q29 hypothetical protein BC007882 SMP3 3q29 SMP3 mannosyltransferase LOC389190 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MFI2 3q28-q29 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 LOC391609 3 similar to immediate early protein homolog DLG1 3q29 discs, large (Drosophila) homolog 1 LOC391610 3 LOC391610 BDH 3q29 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) LOC220729 3q29 similar to succinate dehydrogenase flavoprotein subunit LOC389191 3 hypothetical gene supported by BC053580 KIAA0226 3q29 KIAA0226 gene product DKFZp761B1514 3q29 hypothetical protein DKFZp761B1514 MGC4126 3q29 hypothetical protein MGC4126 DKFZp434B227 3q29 hypothetical protein DKFZp434B227 RPL35A 3q29-qter ribosomal protein L35a LMLN 3q29 leishmanolysin-like (metallopeptidase M8 family) LOC348840 3q29 hypothetical protein LOC348840 LOC389192 3 similar to FSHD Region Gene 2 protein LOC389193 3 hypothetical gene supported by BC014971; NM_020040
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2175 18 156 - 2010 21326824
    4 - 2016 11.8 103 - 2010 21326824
  • CBP20S
  • an in-frame deletion, leading to the translation of a protein lacking most of the RNA recognition motif (RRM)
  • does bind mRNA, is localized to an active transcription site and redistributed to nucleolar caps upon transcription inhibition
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RNA recognition motif
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ncbp2
    Homologene
    FAMILY
  • RRM NCBP2 family
  • CATEGORY RNA associated , transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in mediating u snRNA export from the nucleus. binds to 5'capped mRNA
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCBP1, NCBP2 independently interact with EIF4GI
  • NCBP1/NCBP2 initially undergo a pioneer round of translation (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS