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FLASH GENE
Symbol NCBP2 contributors: mct - updated : 29-01-2013
HGNC name nuclear cap binding protein subunit 2, 20kDa
HGNC id 7659
Location 3q29      Physical location : 196.662.272 - 196.669.464
Synonym name
  • cell proliferation-inducing gene 55 protein
  • NCBP interacting protein 1
  • Synonym symbol(s) NIP1, CBP20, CBC2, PIG55
    DNA
    TYPE functioning gene
    STRUCTURE 7.19 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2175 18 156 - 2010 21326824
    4 - 2016 11.8 103 - 2010 21326824
  • CBP20S
  • an in-frame deletion, leading to the translation of a protein lacking most of the RNA recognition motif (RRM)
  • does bind mRNA, is localized to an active transcription site and redistributed to nucleolar caps upon transcription inhibition
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RNA recognition motif
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ncbp2
    Homologene
    FAMILY
  • RRM NCBP2 family
  • CATEGORY RNA associated , transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in mediating u snRNA export from the nucleus. binds to 5'capped mRNA
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCBP1, NCBP2 independently interact with EIF4GI
  • NCBP1/NCBP2 initially undergo a pioneer round of translation (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS