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FLASH GENE
Symbol NCAPD3 contributors: mct - updated : 25-06-2019
HGNC name non-SMC condensin II complex, subunit D3
HGNC id 28952
Corresponding disease
MCPH22 microcephaly 22, primary, autosomal recessive
Location 11q25      Physical location : 134.022.336 - 134.094.426
Synonym name
  • chromosome condensation protein D3
  • KIAA0056 protein
  • condensin-II complex subunit D3
    • Synonym symbol(s) CAP-D3, hHCP-6, KIAA0056, FLJ42888, hcp-6, MGC104671, CAPD3, MCPH22, hCAP-D3,
    DNA
    TYPE functioning gene
    STRUCTURE 73.01 kb     35 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    35 - 5661 169 1498 - 2003 14532007
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     liver   moderately
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
     thymus   lowly
    Reproductivemale systemprostate  highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may playing an essential role in mitotic chromosome assembly and segregation
    • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • initial phase of chromosome condensation requires CDK1-mediated phosphorylation of the NCAPD3 subunit of condensin II
  • down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
  • Condensin II subunits, NCAPD3 and NCAPH2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a new biomarker for subtype-1 prostate tumors that improves prognostication, and reveal androgen signaling as an important biologic feature of this potentially clinically favorable molecular subtype
    • Therapy target
    ANIMAL & CELL MODELS