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FLASH GENE
Symbol NBR2 contributors: - updated : 18-03-2006
HGNC name neighbor of BRCA1 gene 2
HGNC id 20691
Location 17q21      Physical location : 41.277.599 - 41.297.123
Synonym name
  • membrane component chromosome 17,surface marker 2-like
  • Synonym symbol(s) 1A1.3 , M17S2L
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text next to BRCA1
    STRUCTURE 19.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure share a bi-directional promoter
    MAPPING cloned Y linked N status provisional
    Map see BRCA1 BRCA1 ,M17S2
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • duplicated sequence 1A1.3B
  • a B box zinc finger coiled coil domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION putatively involved in BRCA1 regulation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein constituent of membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS