Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NBPF1 contributors: mct/npt - updated : 11-05-2010
HGNC name neuroblastoma breakpoint family, member 1
HGNC id 26088
Location 1p36.13      Physical location : 16.890.411 - 16.939.982
Synonym name hypothetical protein LOC55672
Synonym symbol(s) AB13, AB14, AB23, FLJ20719, KIAA1693, NBG, NBPF
DNA
TYPE functioning gene
STRUCTURE 49.57 kb     28 Exon(s)
motif repetitive sequence
text structure repetitive structure with high intragenic and intergenic sequence similarity in both coding and noncoding regions (Vandepoele 2005)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 4568 - 1214 - Vandepoele (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • highly conserved domain of unknown function, the NBPF repeat (Vandepoele 2005)
  • a coiled-coil region interacting with the coiled-coil domain in the C-terminal region of Chibby, CBY1 (Vandepoele 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • neuroblastoma breakpoint (NBPF) family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in tumor aggressiveness (Vandepoele 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CBY1 and clusterin (formation of a tri-molecular complex)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    disrupted by a constitutional translocation in a neuroblastoma (Vandepoele 2009)
    tumoral   translocation    
    translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupting the NBPF1 and ACCN1 (Vandepoele 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS