basic FUNCTION
| involved in double-strand break repair by end joining (non homologous recombination) and cell-cycle checkpoint functions |
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acting as a major effector of ATM kinase |
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role in maintenance of telomeres and in tumor development |
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playing an essential role for viability of proliferating cells |
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playing a role in the repair of irradiation damage, maintenance of chromosomal stability and the recombination of Ig constant region genes in B lymphocytes |
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playing a role in cerebellar development |
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playing an active role in ATM activation beyond translocating Mre11/Rad50 to the nucleus and this function requires nibrin-ATM interaction |
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can regulate neuronal proliferation and neuroprotection via PI 3-kinase/Akt pathway while regulating neuronal differentiation in a different pathway |
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plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50 |
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overexpression inducing epithelial-mesenchymal transition through the upregulation of SNAIl expression, and co-expression of NBN/SNAI1 predicts metastasis in head and neck squamous cell carcinoma |
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nuclear export of nibrin may function, in part, to downregulate posttranslationally modified MRN complex components after DNA damage responses |
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its functions in both repair of V(D)J-generated DSBs and proliferation are essential for T-cell development |
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is one important target of RNF8 to regulate DNA DSB repair |
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ATM phosphorylation of NBN is required for the activation of the S-phase checkpoint |
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phosphorylation of NBN regulates its accumulation, and that of ATM, at sites of DNA DSB as well as the timing of the repair of these sites |
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plays unique and essential roles in ATM activation in response to DNA double-strand breaks |
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NBN and TOPBP1 have the potential to activate ATR independently, although both are required for functional activation of ATR |
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NBN and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair |
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NBN and ATM collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner |