Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NBL1 contributors: mct - updated : 13-09-2014
HGNC name neuroblastoma, suppression of tumorigenicity 1
HGNC id 7650
Location 1p36.13      Physical location : 19.969.725 - 19.984.945
Synonym name differential screening-selected gene aberrant in neuroblastoma (see TSG1A, CDC2L1, CDC2L2, CDC2L3)
Synonym symbol(s) D1S733E, DAN, NB, NO3, DAND1
DNA
TYPE functioning gene
STRUCTURE 5.23 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D1S80 - D1S243 - D1S468 - D1S2845 - D1S2893 - D1S2660 - D1S2633 - D1S2795 - D1S253 - D1S2870 - D1S2731 - [D1S214 - D1S2642 - D1S2663 - D1S2694 ] - D1S2666 - D1S508 - D1S160 - D1S450 - D1S244 - D1S2736 - D1S503 - cen
Authors Bauer (01)
Text [NBL1 minimal SRO deletion]
Physical map
FLJ38753 1p36.13 hypothetical protein FLJ38753 LOC391012 1 similar to Putative dynein light chain protein DJ8B22.1 PAX7 1p36.2-p36.12 paired box gene 7 TAS1R2 1p36.13 taste receptor, type 1, member 2 ALDH4A1 1p36 aldehyde dehydrogenase 4 family, member A1 RBAF600 1p36.13 retinoblastoma-associated factor 600 KIAA0090 1p36.13 retinoblastoma-associated factor 600 C1orf33 1p36.13 chromosome 1 open reading frame 33 AFAR3  aflatoxin B1 aldehyde reductase 3 AKR7A3 1p35.1-p36.23 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) AKR7A2 1p36.1-p35 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) FLJ20320 CAPZB 1p36.1 capping protein (actin filament) muscle Z-line, beta LOC388600 1 similar to protein of fungal metazoan origin like (11.1 kD) (2C514) NBL1 1p36.13-p36.11 neuroblastoma, suppression of tumorigenicity 1 HTR6 1p36-p35 5-hydroxytryptamine (serotonin) receptor 6 LOC255104 1p36.13 hypothetical protein LOC255104 FLJ20225 1p36.13 hypothetical protein FLJ20225 LOC254897 1p36.13 similar to OSJNBa0043A12.32 PLA2G2E 1p36.13 similar to OSJNBa0043A12.32 PLA2G2A 1p36.1-p35 phospholipase A2, group IIA (platelets, synovial fluid) PLA2G5 1p36-p34 phospholipase A2, group V PLA2G2D 1p36.12 phospholipase A2, group IID PLA2G2F 1p35 phospholipase A2, group IID LOC391013 1 similar to Group IIC secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GIIC) (GIIC sPLA2) (PLA2-8) (14 kDa phospholipase A2) FLJ25429 FLJ32784 1p36.13 hypothetical protein FLJ32784 LOC388601 1 LOC388601 CaMKIINalpha 1p36.13 calcium/calmodulin-dependent protein kinase II FLJ12875 1p36.13 hypothetical protein FLJ12875 LOC163933 1p36.12 similar to cDNA sequence BC022623 CDA 1p36.2-p35 cytidine deaminase PINK1 1p36 PTEN induced putative kinase 1 DDOST 1p36.1 dolichyl-diphosphooligosaccharide-protein glycosyltransferase KIF17 1p36.13 kinesin family member 17 LOC388602 1 LOC388602 LOC388603 1 LOC388603 HP1-BP74 1p36.12 HP1-BP74 EIF4G3 11p15 eukaryotic translation initiation factor 4 gamma, 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2079 - 216 - 1997 9324305
4 - 2060 - 181 - 1997 9324305
4 - 2127 - 181 - 1997 9324305
4 - 2151 - 181 - 1997 9324305
4 - 2184 - 181 - 1997 9324305
4 - 2069 - 181 - 1997 9324305
4 - 2178 - 215 - 1997 9324305
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary    Homo sapiens
 male systemprostate  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegranulosa cell Homo sapiens
cell lineage
cell lines of memingioma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
cystine-knot domain
HOMOLOGY
interspecies homolog to mammalian dan
homolog to murine NbL1
Homologene
FAMILY
CATEGORY transcription factor , tumor suppressor
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • is a novel autocrine/paracrine factor that modulates GNRHR function in pituitary gonadotropes
  • is indispensable for NODAL expression in the in the lateral plate mesoderm (LPM) and for Lefty-1 expression in the notochord
  • might act synergistically with NODAL
  • plays an essential role in the establishment of the L-R axis by inhibiting BMP signaling around the node
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBQLN1/NBL1 complex might play a crucial role in the regulation of the cell cycle progression
  • inhibited BMP signaling but not NODAL signaling
  • specifically can antagonize BMP2 and BMP4 and modulates the actions of GDF9, BMP2, and BMP4 ovary
  • cell & other
    REGULATION
    activated by mRNA expression in granulosa cells was up-regulated by oocyte-derived growth differentiation factor 9 (GDF9)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    correlated with prostate carcinoma progression
    Susceptibility to neuroblastoma
    Variant & Polymorphism
    Candidate gene
    Marker
  • NBL1 and anillin are promising markers for pancreatic carcinoma molecular diagnostics
  • NBL1 might be a candidate tumor marker for prostate carcinoma in addition to PSA
  • Therapy target
    ANIMAL & CELL MODELS