basic FUNCTION
| presumptive protein kinase A anchoring function |
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may be involved in membrane trafficking events |
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neuron-specific multidomain protein implicated in membrane trafficking that is predominantly expressed in the brain and during development |
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putative regulator of membrane protein trafficking associated with tubulovesicular endomembranes and postsynaptic plasma membranes |
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function at central synapses that may be based on its presumed role in targeting membrane proteins to synaptic contact |
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role of VPS35 and NBEA in the retrieval and post-Golgi trafficking of synaptic GLYRs and possibly other neurotransmitter receptors |
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potential roles of VPS35 and NBEA in inhibitory receptor trafficking |
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potential role in trafficking important cargo to pre- and postsynaptic compartments |
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regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses |
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potential risk gene in human obesity |
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is important also for the functioning of central synapses, where it is suggested to play a role in trafficking membrane proteins to both, the pre- and post-synaptic sites |
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regulates synaptic transmission under basal conditions by targeting neurotransmitter receptors to synapses |
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acts as a critical regulator in the postsynaptic neuron for the coordination of dendritic morphology with synaptogenesis |
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brain specific, and is required for synaptic surface expression of both glutamate and GABA receptors |
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regulates glutamate- and GABA-Receptor targeting to synapses via distinct pathways |
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role for NBEA as transcriptional regulator in the nucleus |