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FLASH GENE
Symbol NAV2 contributors: mct - updated : 23-09-2019
HGNC name neuron navigator 2
HGNC id 15997
Location 11p15.1      Physical location : 19.372.270 - 20.143.146
Genatlas name pore membrane and/or filament interacting like protein 2
Synonym name
  • retinoic acid-inducible gene in neuroblastoma 1
  • helicase, APC down-regulated 1
  • pore membrane and/or filament-interacting-like protein 2
  • retinoic acid inducible gene in neuroblastoma 1
  • steerin-2
  • unc-53 homolog 2
  • Synonym symbol(s) HELAD1, RAINB1, POMFILZ, KIAA1419, POMFIL2, STEERIN2, UNC53H2, FLJ10633, FLJ11030, FLJ23707
    EC.number 3.6.4.12
    DNA
    TYPE functioning gene
    STRUCTURE 776.40 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 splicing 11492 - 2429 - 2013 24161943
  • NAV2-IL
  • 39 splicing 11501 - 2432 - 2013 24161943
    38 - 10687 - 2365 - 2013 24161943
    41 - 11669 - 2488 - 2013 24161943
    28 - 8082 - 1493 - 2013 24161943
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Digestiveintestinesmall intestinejejunum  
    Nervousbrainhindbraincerebellum highly Homo sapiens
    Reproductivefemale systemuterus   
    Respiratorylung    
    Urinarybladder    
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta,fetal brain and heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal CH (calponin homology) domain
  • several coiled-coil domains
  • conserved AAA motif
  • HOMOLOGY
    interspecies homolog to C.elegans Unc53
    Homologene
    FAMILY NAV gene family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • all-trans retinoic acid (atRA) -responsive gene
  • functions in mammalian nervous system development, and is required for normal cranial nerve development and blood pressure regulation in the adult
  • essential role for full-length NAV2 in cerebellar development, including axonal elongation and migration of the external granule layer (EGL) neurons
  • involved in the nervous system development and may play a role in Alzheimer disease (AD)
  • NAV2 could likely induce melanoma proliferation and invasion by epithelial-mesenchymal transition through the GSK3B/CTNNB1-SNAI2 pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between NAV2 and YWHAE could provide insight into the mechanism by which NAV2 participates in promoting cell migration and neuronal elongation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Alzheimer disease (AD) and variation of age at onset (AAO)
  • Variant & Polymorphism other
  • several genetic variants within the NAV2 gene influencing the risk and age at onset (AAO) of Alzheimer disease (AD)
  • Candidate gene
    Marker
  • NAV2 and CCND2 are novel candidate prognostic markers in uterine leiomyosarcoma (LMS) andlow-grade endometrial stromal sarcoma (LG-ESS), respectively
  • Therapy target
    ANIMAL & CELL MODELS