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FLASH GENE
Symbol NAT2 contributors: npt/ - updated : 13-10-2007
HGNC name N-acetyltransferase 2 (arylamine N-acetyltransferase)
HGNC id 7646
Corresponding disease
NAT2D N-acetyltransferase 2 (arylamine N-acetyltransferase) deficiency
Location 8p22      Physical location : 18.248.754 - 18.258.723
Synonym name
  • arylamide acetylase 2 (N-acetyltransferase 2,isomiazid inactivation)
  • N- acetyltransferase type 2
  • polymorphic arylamine N-acetyltransferase
  • Synonym symbol(s) AAC2, ARY2, PNAT, NAT-2
    EC.number 2.3.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 9.97 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    N33 8p22 hypothetical protein LOC286114 LOC137012 8p22 protein phosphatase 1A pseudogene LOC392202 8 similar to 60S ribosomal protein L32 MSR1 8p22 macrophage scavenger receptor 1 LOC392203 8 similar to matricin MRPL49P2 8p22 similar to matricin FGF20 8p22-p21.3 fibroblast growth factor 20 LOC286097 8p22 hypothetical protein LOC286097 ZDHHC2 8p21.3-p22 zinc finger, DHHC domain containing 2 CNOT7 8p22-p21.3 CCR4-NOT transcription complex, subunit 7 FLJ32642 8p22 hepatocellular carcinoma related protein 1 MTMR7 8p22 myotubularin related protein 7 LOC392204 8 similar to ADAM 25 precursor (A disintegrin and metalloproteinase domain 25) (Testase 2) SLC7A2 8p22-p21.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 PDGFRL 8p22-p21.3 platelet-derived growth factor receptor-like MTSG1 8p22 mitochondrial tumor suppressor gene 1 LOC389636 8 LOC389636 FGL1 8p22-p21.3 fibrinogen-like 1 PCM1 8p22-p21.3 pericentriolar material 1 ASAH1 8p22-p21.3 N-acylsphingosine amidohydrolase (acid ceramidase) 1 MRPS18CP3 8p21.3 mitochondrial ribosomal protein S18C pseudogene 3 UNQ9391 8p23.1 tryptophan/serine protease NAT1 8p22 N-acetyltransferase 1 (arylamine N-acetyltransferase) LOC392205 8 similar to acetyltransferase LOC392206 8 similar to ribosomal protein L10a NAT2 8p22 N-acetyltransferase 2 (arylamine N-acetyltransferase) DKFZp761K1423 8p22 hypothetical protein DKFZp761K1423 EFA6R 8pter-p23.3 hypothetical protein DKFZp761K1423 LOC389637 8 LOC389637 LOC389638 8 LOC389638 LOC392207 8 similar to PMCA2av FLJ20967 8p21.2 hypothetical protein FLJ20967 ChGn 8p21.3 chondroitin beta1,4 N-acetylgalactosaminyltransferase FLJ10569 8p21.3 hypothetical protein FLJ10569 LPL 8p22 lipoprotein lipase SLC18A1 8p21.3 solute carrier family 18 (vesicular monoamine), member 1 ATP6V1B2 8p22 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 LZTS1 8p22 leucine zipper, putative tumor suppressor 1 RNU3P2 8p21.3 RNA, U3 small nucleolar pseudogene 2 LOC286114 8p21.3 hypothetical protein LOC286114
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1317 33 290 - Ohsako (1990)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   predominantly
     liver   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Nat2
    homolog to rattus nat1
    Homologene
    FAMILY
  • arylamine N-acetyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • arylamine N-acetyltransferase 2, polymorphic
  • responsible for slow or rapid acetylation of arylamine and hydrazine drugs and able to bioactivate several known carcinogens
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NAT2D
    related resource Arylamine N-Acetyltransferase (Note- Not really a variation database but useful-lists alleles & nomenclature)
    Susceptibility
  • susceptibility gene for bladder cancer
  • putative susceptibility factor in squamous-cell carcinoma of the esophagus and colorectal cancer and in systemic lupus erythematosus
  • putative susceptibility factor for idiopathic talipes equinovarus (clubfoot)
  • sucseptibility to age-related hearing impairment
  • to drug-induced hepatotoxicity in tuberculosis and rheumatoid arthritis patients
  • Variant & Polymorphism other
  • in slow activator male patients, particularly when the genotype NAT2*5B/6A was combined with the GTSM1 null phenotype and breast cancer and the genotype NAT2*7 is an important factor in tumorigenesis of colorectal cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS