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FLASH GENE
Symbol NASP contributors: mct - updated : 09-09-2013
HGNC name nuclear autoantigenic sperm protein (histone-binding)
HGNC id 7644
Location 1p34.1      Physical location : 46.049.659 - 46.084.576
Synonym name
  • homolog of Xenopus N1/N2
  • histone H1-binding protein
  • nuclear autoantigenic sperm protein autosomal variant
  • Synonym symbol(s) FLB7527, MGC2297, PRO1999, FLJ31599, FLJ35510, MGC19722, MGC20372, DKFZp547F162, N1/N2-like
    DNA
    TYPE functioning gene
    STRUCTURE 34.92 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626 PTCH2 1p32.3-p32.1 patched homolog 2 (Drosophila) EIF2B3 1p34.1 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa LOC128192 1p34.1 similar to peptidyl-Pro cis trans isomerase FLJ21156 1p34.1 hypothetical protein FLJ21156 UROD 1p34 uroporphyrinogen decarboxylase ZSWIM5 1p34.1 zinc finger, SWIM domain containing 5 MGC15668 1p34.1 hypothetical protein MGC15668 MUTYH 1p34.3-p32.1 mutY homolog (E. coli) TOE1  target of EGR1, member 1 (nuclear) TESK2 1p32 testis-specific kinase 2 LOC126661 1p34.1 hypothetical protein LOC126661 DKFZP564I122 1p34.1 DKFZP564I122 protein PRDX1 1p34.1 peroxiredoxin 1 AKR1A1 1p33-p32 aldo-keto reductase family 1, member A1 (aldehyde reductase) NASP 1p34.1 nuclear autoantigenic sperm protein (histone-binding) FLJ33084 1p34.1 hypothetical protein FLJ33084 SP192 1p34.1 hypothetical protein SP192 LOC51249 1p34.1 hypothetical protein LOC51249 IPP 1p34-p32 intracisternal A particle-promoted polypeptide MAST205 1p33 intracisternal A particle-promoted polypeptide PIK3R3 1p34.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) LOC388627 1 LOC388627 TSPAN-1 1p34.1 tetraspan 1 FLJ20277 RAD54L 1p32 RAD54-like (S. cerevisiae) MUF1 1p34.1 RAD54-like (S. cerevisiae) UQCRH 1p34.1 ubiquinol-cytochrome c reductase hinge protein MGC22960 1p34 MGC22960 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing initiation site 3302 85.2 788 testis, spermatocytes, spermatid, spermatozoid 2012 2196553
  • isoform 2 tNASP, testicular NASP
  • characterization of a sperm NASP
  • critical for the survival of prostate cancer cells, suggesting that targeting tNASP expression can lead to a new approach for prostate cancer treatment
  • its role is to provide the functional link between linker histones and cell cycle progression during meiosis
  • 14 splicing initiation site 2294 - 449 all mitotic cells (adult embryonic) during five phases 2012 2196553
  • isoform 3 sNASP, somatic NASP
  • characterization of the histone H1-binding protein as a cell-cycle regulated somatic protein
  • possesses a unique binding specificity in that it forms specific complexes with both histone H1 and histones H3/H4
  • efficiently promoted the assembly of nucleosomes containing the conventional H3.1, H3.2, H3.3, or centromere-specific CENPA
  • - splicing initiation site 3396 - 790 - 2012 2196553
    13 - 3109 - 724 - 2012 2196553
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • TRP1-2-3 (tetratricopeptid) repeats
  • from coiled coil
  • glu-rich (acidic)
  • leucine-zipper
  • nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to murine Nasp
    homolog to C.elegans F58G11.1A
    homolog to xenopus N11N2
    Homologene
    FAMILY nuclear autoantigenic sperm protein (NASP) family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text tNASP : Golgi and acrosome nucleus, 5NASP:nuclear localization
    basic FUNCTION
  • transporting histones into the nucleus of dividing cells (isoform 3)
  • directly promotes nucleosome assembly, providing compelling evidence that sNASP is a bona fide histone chaperone for H3.H4
  • specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain
  • unique genuine chaperone for histone H1
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • GTP
  • protein
  • binding to H1 histones
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • TRA2B is involved in splicing processes of NASP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS