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FLASH GENE
Symbol NARF contributors: mct - updated : 21-05-2008
HGNC name nuclear prelamin A recognition factor
HGNC id 29916
Location 17q25.3      Physical location : 80.416.059 - 80.446.141
Synonym name
  • LET1 like/JFP15
  • protein related to Narf
  • prenyl-dependent prelamin A binding protein
  • Synonym symbol(s) FLJ10067, IOP2
    DNA
    TYPE functioning gene
    STRUCTURE 29.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC13090 17q25.3 hypothetical protein MGC13090 MAFG 17q25 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) LOC92659 17q25.3 hypothetical protein BC009233 PYCR1 17q25.3 pyrroline-5-carboxylate reductase 1 LOC255275 17q25.3 similar to myeloid-associated differentiation marker LOC147111 17q25.3 hypothetical protein LOC147111 ASPSCR1 17q25 alveolar soft part sarcoma chromosome region, candidate 1 STRA13 17q25.3 stimulated by retinoic acid 13 MGC20806 17q25.3 hypothetical protein MGC20806 RAC3 10q25.3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) DCXR 17q25.3 dicarbonyl/L-xylulose reductase GPS1 17q25.3 G protein pathway suppressor 1 PP3111 17q25.3 PP3111 protein FASN 17q25 fatty acid synthase FLJ23754 17q25.3 hypothetical protein FLJ23754 LOC284001 17q25.3 hypothetical protein LOC284001 SLC16A3 17q25 solute carrier family 16 (monocarboxylic acid transporters), member 3 LOC388434 17 LOC388434 CSNK1D 17q25.2-q25.3 casein kinase 1, delta CD7 17q25.2-q25.3 CD7 antigen (p41) SECTM1 17q25.2-q25.3 secreted and transmembrane 1 GPR14 17q25.3 G protein-coupled receptor 14 FLJ22222 17q25.3 hypothetical protein FLJ22222 FLJ23825 17q25.3 hypothetical protein FLJ23825 MGC4368 17q25.3 hypothetical protein MGC4368 NARF 17q25.3 nuclear prelamin A recognition factor ILF1 17q25.2 interleukin enhancer binding factor 1 PRO0478 17q25.3 PRO0478 protein DKFZp434D1428 17q25.3 hypothetical protein DKFZp434D1428 LOC56270 17q25.3 hypothetical protein 628 RAB40B 17q25.3 RAB40B, member RAS oncogene family FLJ12171 FN3K 17q25.3 RAB40B, member RAS oncogene family TBCD 17q25.3 tubulin-specific chaperone d
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 polyA site 1638 - 456 - Barton (1999), Lattanzi (2007)
    2 potential nuclear localization signals
    - polyA site 1776 56.2 502 - Barton (1999), Lattanzi (2007)
    biological validity not determined experimemtally
    - - 1796 - 397 - Lattanzi (2007)
    - - 1494 - 408 - Lattanzi (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  lowly
     liver   lowly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix lowly
     male systemtestis  moderately
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
  • moderate to poorly differentiated invasive carcinoma
  • liposarcoma
  • follicular carcinoma
  • endometrioid ovarian metastasis
  • fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope,lamina
    text
  • colocalized with LMNA at the nuclear lamina
  • basic FUNCTION
  • nemo-like kinase (NLK)-associated ring finger protein that regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor
  • involved in electron transport
  • having ferredoxin hydrogenase activity
  • involved in heterochromatin organization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of a prelamin A endoprotease complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically binding to the farnesylated prelamin A C-terminal domain (preAct)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS