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FLASH GENE
Symbol NAPG contributors: mct - updated : 22-10-2012
HGNC name N-ethylmaleimide-sensitive factor attachment protein, gamma
HGNC id 7642
Location 18p11.22      Physical location : 10.525.872 - 10.552.762
Synonym name
  • gamma SNAP
  • soluble NSF attachment protein
  • Synonym symbol(s) GAMMASNAP
    DNA
    TYPE functioning gene
    STRUCTURE 26.89 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0802 18p11.21 AFG3 ATPase family gene 3-like 2 (yeast) LOC390830 18 similar to ribosomal protein S4, X-linked NDUFV2 18p11.22-p11.21 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa KIAA0874 TWSG1 18p11.3-p11.2 twisted gastrulation homolog 1 (Drosophila) RALBP1 18p11.3 ralA binding protein 1 PPP4R1 18p11.22 protein phosphatase 4, regulatory subunit 1 LOC125242 18p11.22 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RAB31 18p11.31-p11.22 RAB31, member RAS oncogene family TXNDC2 18p11.31-p11.2 thioredoxin domain containing 2 (spermatozoa) VAPA 18p11.21 VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa APCDD1 18p11.21 adenomatosis polyposis coli down-regulated 1 NAPG 18p11.21 N-ethylmaleimide-sensitive factor attachment protein, gamma LOC390831 18 similar to Phosphomannomutase 2 (PMM 2) FLJ23403 18p11.21 hypothetical protein FLJ23403 LOC342843 18p11.21 similar to hypothetical protein LOC284221 18p11.21 hypothetical protein LOC284221 FLJ34907 18p11.21 hypothetical protein FLJ34907 LOC388463 18 similar to acyl-malonyl condensing enzyme LOC388464 18 hypothetical gene supported by D86974 GNAL 18p11.31 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type CHMP1.5 18p11.21 CHMP1.5 protein MPPE1 18p11.21-p11.1 CHMP1.5 protein IMPA2 18p11.22-p11.21 inositol(myo)-1(or 4)-monophosphatase 2 LOC284226 18p11.21 similar to Kinesin-like protein KIF1C LOC284227 18p11.21 similar to single stranded DNA binding protein 4 LOC162835 18p11.21 similar to G protein-coupled receptor 124 LOC342850 18p11.21 similar to KIAA1074 protein LOC390832 18 similar to Phosphomannomutase 2 (PMM 2) CIDEA 18p11.21 cell death-inducing DFFA-like effector a MGC4083 18p11.21 tubulin beta MGC4083 AFG3L2 18p11 AFG3 ATPase family gene 3-like 2 (yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3729 - 312 - 2003 12554740
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Napg
    homolog to Drosophila 8ggi.Snap
    homolog to C.elegans Y59A8B.8
    homolog to rattus LOC307382
    Homologene
    FAMILY SNAP family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • required for the membrane fusion and vesicular transport between the endoplasmic reticulum and the Golgi apparatus
  • meditates platelet exocytosis and controls the membrane fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to NSF
  • interacting with GAF1
  • RAB11FIP5 participates in endosomal recycling through the interaction with both NAPG, a member of the soluble NSF attachment protein family, and a small GTPase, RAB11A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bipolar disorder
    Variant & Polymorphism SNP
  • rs2290279, rs495484 and rs510110, show a nominal, statistically significant association with bipolar disorder
  • Candidate gene
  • candidate for susceptibility to bipolar disorder
  • Marker
    Therapy target
    ANIMAL & CELL MODELS