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FLASH GENE
Symbol NAP1L1 contributors: mct/npt - updated : 29-03-2014
HGNC name nucleosome assembly protein 1-like 1
HGNC id 7637
Location 12q21.2      Physical location : 76.438.671 - 76.478.738
Synonym name
  • HSP22-like protein interacting protein
  • NAP-1 related protein
  • nucleosome assembly protein 1
  • Synonym symbol(s) NRP, NAP1, NAP1L, FLJ16112, MGC8688, MGC23410
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text tightly linked to DXS990
    STRUCTURE 40.07 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status confirmed
    Physical map
    RAB21 12q13.3 RAB21, member RAS oncogene family FLJ12085 TPH2 12q15 tryptophan hydroxylase 2 TRHDE 12q15-q21 Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme (TRHDE), mRNA. VENTX2P3 12q15 VENT-like homeobox 2 pseudogene 3 LOC387869 12 LOC387869 LOC390343 12 similar to microtubule-associated proteins 1A/1B light chain 3 KCNC2 19q13.4 potassium voltage-gated channel, Shaw-related subfamily, member 2 CAPS2 12q21.1 calcyphosphine 2 MGC26856 12q21.1 hypothetical protein MGC26856 MGC39497 12q21.1 hypothetical protein MGC39497 GLIPR1 12q21.1 GLI pathogenesis-related 1 (glioma) HRB2 12q21.1 HIV-1 rev binding protein 2 LOC390344 12 similar to 6-phosphogluconate dehydrogenase, decarboxylating LOC390345 12 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) PHLDA1 12q15 pleckstrin homology-like domain, family A, member 1 NAP1L1 12q15 nucleosome assembly protein 1-like 1 LOC121071 12q21.1 similar to NOGO-interacting mitochondrial protein FLJ23560 12q21.1 hypothetical protein FLJ23560 OSBPL8 12q14 oxysterol binding protein-like 8 LOC123031 12q21.1 similar to 60S ribosomal protein L21 HIP14 12q14-q15 similar to 60S ribosomal protein L21 CSRP2 12q21.1 cysteine and glycine-rich protein 2 LOC390346 12 similar to Ran-specific GTPase-activating protein (Ran binding protein 1) (RanBP1) E2F7 12q21.1 E2F transcription factor 7 NAV3 12q21.1 neuron navigator 3 MRPL11P3 12q21.2 neuron navigator 3 LOC390347 12 similar to ras related v-ral simian leukemia viral oncogene homolog A SYT1 12q15-q21 synaptotagmin I LOC338756 12q21.2 similar to hypothetical protein PAWR 12q21.2-q21.32 PRKC, apoptosis, WT1, regulator PPP1R12A 12q15-q21 protein phosphatase 1, regulatory (inhibitor) subunit 12A LOC120872 12q21.2 similar to ribosomal protein L7 LOC283308 12q21.2 similar to 60S ribosomal protein L26
    RNA
    TRANSCRIPTS type messenger
    text both variants encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 polyA site 4451 45.2 391 - 2007 17339334
    15 polyA site 5125 45.2 391 - 2007 17339334
    differing by 3' UTR compared to variant 1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunetonsils   predominantly
    Nervousbrain   specific
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion moderately in lymph
    at STAGE
    physiological period fetal
    Text highly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential nuclear localization signal (NLS)
  • three clusters of acidic residues and other motifs (acidic domains probably involved in the interaction with histones)
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to rattus Nap1l1 (98.2 pc)
    homolog to murine Nap1l1 (98.2 pc)
    intraspecies paralog to NAP1L*
    Homologene
    FAMILY
  • nucleosome assembly protein (NAP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text
  • nucleocytoplasmic shuttling protein (Calvert 2008)
  • localized mainly to the cytoplasm and a minor population of them was suggested to be in the nucleus (Okuwaki 2010)
  • basic FUNCTION
  • may be involved in modulating chromatin formation
  • contributing to regulation of cell proliferation
  • participating in DNA replication
  • cofactor for the import of histones H2A and H2B, a chromatin assembly factor and a mitotic factor involved in regulation of bud formation (Calvert 2008)
  • cooperates with EP300 in eviction of the acetylated histones from the chromatin template (Sharma 2008)
  • promotes nucleosome assembly by eliminating nonnucleosomal histone DNA interactions (Andrews 2010)
  • histone chaperone protein suspected to be involved in the dynamical regulation of the histone H2A-H2B hetero-dimer (Okuwaki 2010)
  • with NAP1L4 mediated nucleosome formation (Okuwaki 2010)
  • possess a significantly greater nucleosome disassembly activity than NAP1L4, suggesting that NAP1L1 and NAP1L4 may play distinct roles in the regulation of histone dynamics (Okuwaki 2010)
  • is required for cohesin release and sister chromatid resolution during mitosis
  • NAP1L1 binding to cohesin is cell-cycle regulated and increases during G2/M phase
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, chromatin organization, remodeling
    nucleotide, replication
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibiting acetylation of core histones by EP300
  • interacting with TTLL10 (Ikegami 2008)
  • balanced antagonism between NAP1L1 and PP2A controls cohesin dissociation during mitosis
  • cell & other
    REGULATION
    Other prenylated
    phosphorylation by CSNK2A1 appears to regulate its localization and is required for normal progression through S phase (Calvert 2008)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS