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FLASH GENE
Symbol NAGPA contributors: - updated : 11-04-2007
HGNC name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
HGNC id 17378
Location 16p13.3      Physical location : 5.074.845 - 5.083.942
Synonym name
  • mannose 6-phosphate-uncovering enzyme
  • lysosomal alpha-N-acetylglucosaminidase
  • mannose 6-phosphate-uncovering enzyme
  • phosphodiester alpha-GlcNAcase
    • Synonym symbol(s) APAA, UCE
    EC.number 3.1.4.45
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 9.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ADCY9 16p13.3 adenylate cyclase 9 LOC388208 16 LOC388208 SRL 16p13.3 sarcalumenin TFAP4 16p13 transcription factor AP-4 (activating enhancer binding protein 4) GLIS2 16p13.3 Kruppel-like zinc finger protein GLIS2 Magmas 16p13.3 mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction FLJ22021 16p13.3 hypothetical protein FLJ22021 DNAJA3 16p13.3 DnaJ (Hsp40) homolog, subfamily A, member 3 HSCARG 16p13.3 HSCARG protein HMOX2 16p13.3 heme oxygenase (decycling) 2 C16orf5 16p13.3 heme oxygenase (decycling) 2 LOC342346 16p13.3 similar to hypothetical protein DKFZp434P0316 LOC124402 16p13.3 LOC124402 MGRN1 16p13 mahogunin, ring finger 1 SDOS 16p13.3 hypothetical protein MGC11275 LOC146562 16p13.3 hypothetical protein AF447587 ZNF500 16p13.3 zinc finger protein 500 FLJ25410 16p13.3 hypothetical protein FLJ25410 LOC388209 16 hypothetical gene supported by BC022385; BC035868; BC048326 FLJ22386 16p13.3 leucine zipper domain protein N-PAC 16p13.3 cytokine-like nuclear factor n-pac UBN1 16p13.3 ubinuclein 1 PPL 16p13.3 periplakin KIAA0420 16p13.3 periplakin NAGPA 16p13.3 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase MGC45438 16p13.3 hypothetical protein MGC45438 ALG1 16p13.3 asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC390672 16 similar to chromosome 11 open reading frame2; chromosome 11 open reading frame2 NPM1P3 16p13.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 3 A2BP1 16p13.3 ataxin 2-binding protein
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
    Lymphoid/Immunetonsils   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal signal sequence
  • a transmembrane region
  • six N-glycosylation potential sites
    • mono polymer homomer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • removes a covering N-acetylglucosamine from the mannose-6-phosphate recognition marker on lysosomal acid hydrolases
  • can hydrolyses UDP-GlcNAc
  • involved in trafficking pathway and playing a crucial role in the process of lysosomal biogenesis
    • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    trafficking pathway
    a component homotetramer of two disulfide-linked homodimers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cleavage via the furin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS