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FLASH GENE
Symbol NAGPA contributors: - updated : 11-04-2007
HGNC name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
HGNC id 17378
Location 16p13.3      Physical location : 5.074.845 - 5.083.942
Synonym name
  • mannose 6-phosphate-uncovering enzyme
  • lysosomal alpha-N-acetylglucosaminidase
  • mannose 6-phosphate-uncovering enzyme
  • phosphodiester alpha-GlcNAcase
  • Synonym symbol(s) APAA, UCE
    EC.number 3.1.4.45
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 9.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
    Lymphoid/Immunetonsils   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal signal sequence
  • a transmembrane region
  • six N-glycosylation potential sites
  • mono polymer homomer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • removes a covering N-acetylglucosamine from the mannose-6-phosphate recognition marker on lysosomal acid hydrolases
  • can hydrolyses UDP-GlcNAc
  • involved in trafficking pathway and playing a crucial role in the process of lysosomal biogenesis
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    trafficking pathway
    a component homotetramer of two disulfide-linked homodimers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cleavage via the furin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS