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FLASH GENE
Symbol NAE1 contributors: mct/npt - updated : 25/10/2008
HGNC name NEDD8 activating enzyme E1 subunit 1
HGNC id 621
Location 16q22      Physical location : 66.836.781 - 66.864.879
Synonym name
  • amyloid beta precursor protein binding protein 1, 59kDa
  • amyloid protein-binding protein 1
  • protooncogene protein 1
  • Synonym symbol(s) Fz65, APPBP1, HPP1, ula-1
    DNA
    TYPE functioning gene
    STRUCTURE 28.09 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 1820 60 534 - Park (2008)
    21 - 1918 59.3 528 - Park (2008)
    19 - 1716 50.5 445 - Park (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Arabidosis AXR1
    homolog to ubiquitin-activating enzyme 1 (N terminal region)
    Homologene
    FAMILY
  • Thif family (bacterial)
  • ubiquitin-activating E1 family
  • ULA1 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • amyloid precursor protein (APP) binding protein, that is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8
  • drives the S- to M-phase transition in dividing cells, and causes apoptosis in neurons
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    text ubiquitin mediated proteolysis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complex with APP and histone acetyltransferase (Tip60)
  • component of an E1 (ubiquitin-activating enzyme) like complex consisting of APPB1 and UBE1C
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the COOH-terminal 31 amino acids of APP (C31) and colocalizes with APP in a lipid-enriched fraction called lipid rafts
  • interaction with TRIP12
  • cell & other
    REGULATION
    Other degraded by ubiquitin-dependent proteolysis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in lipid rafts observed in the Alzheimer's disease brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS