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FLASH GENE
Symbol NACA2 contributors: npt - updated : 14-11-2006
HGNC name nascent polypeptide-associated complex alpha subunit 2
HGNC id 23290
Location 17q23.2      Physical location : 59.667.793 - 59.668.563
Synonym name
  • alpha-NAC protein
  • nascent-polypeptide-associated complex alpha polypeptide-like
  • IgE autoantigen alpha-nascent polypeptide-associated complex
  • Synonym symbol(s) MGC71999, ANAC, NACAL
    DNA
    TYPE functioning gene
    STRUCTURE 0.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 803 23 215 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   predominantly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemovary  highly
     male systemprostate  moderately
    Respiratoryrespiratory tractlarynx  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-glycosylation sites
  • several sites for protein phosphorylation
  • C-terminal fragment specifically binding IgE autoantibodies
  • secondary structure mostly of alpha helices and a single beta sheet
    HOMOLOGY
    interspecies ortholog to murine Naca
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • intracellular translocation of newly synthesized polypeptides
  • transcriptional coactivator
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component alpha-nascent polypeptide-associated complex
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • IgE autoantibodies
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS