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FLASH GENE
Symbol NACA contributors: mct - updated : 10-12-2012
HGNC name nascent-polypeptide-associated complex alpha polypeptide
HGNC id 7629
Location 12q13.3      Physical location : 57.106.210 - 57.119.326
Synonym name
  • NAC-alpha
  • skeletal and heart muscle specific variant of nascent polypeptide-associated complex alpha
  • Synonym symbol(s) HSD48, skNAC, NACA1
    EC.number 5.3.99.3
    DNA
    TYPE functioning gene
    STRUCTURE 13.12 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    MBC2 12q13.13 signal transducer and activator of transcription 6, interleukin-4 induced MLC1SA 12q13.13 signal transducer and activator of transcription 6, interleukin-4 induced MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452 CS 12p11-qter citrate synthase TMEM4 12q15 transmembrane protein 4 USP52 12q13.2-q13.3 ubiquitin specific protease 52 APOF 12q13.13 apolipoprotein F IL23A 12q13.2-q13.3 interleukin 23, alpha subunit p19 STAT2 17q11.1-q22 signal transducer and activator of transcription 2, 113kDa LOC390331 12 similar to hypothetical protein FLJ10560 TIMELESS 12q12-q13 timeless homolog (Drosophila) MIP 12q13 major intrinsic protein of lens fiber LOC283377 12q13.13 hypothetical protein LOC283377 GA 12q13 hypothetical protein LOC283377 LOC338801 12q13.13 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) RBMS2 12q12 RNA binding motif, single stranded interacting protein 2 BAZ2A 12q24.3-qter bromodomain adjacent to zinc finger domain, 2A ATP5B 12p13-qter ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide TEBP 12q13.13 unactive progesterone receptor, 23 kD PRIM1 12q13 primase, polypeptide 1, 49kDa NACA 12q23-q24.1 nascent-polypeptide-associated complex alpha polypeptide RODH 12q13 nascent-polypeptide-associated complex alpha polypeptide SDR-O 12q13.13 orphan short-chain dehydrogenase / reductase RODH-4 12q13.13-q13.2 microsomal NAD+-dependent retinol dehydrogenase 4 LOC390332 12 similar to sterol/retinol dehydrogenase ADMR 12q13.3-q14 adrenomedullin receptor KIAA0352 12q13.2-q15 adrenomedullin receptor TAC3 12q13-q21 tachykinin 3 (neuromedin K, neurokinin beta) MYO1A 12q13-q15 myosin IA KIAA0286 12q13.2 KIAA0286 protein NAB2 12q13.3-q14.1 NGFI-A binding protein 2 (EGR1 binding protein 2) STAT6 12q13.3-q14.1 signal transducer and activator of transcription 6, interleukin-4 induced
    RNA
    TRANSCRIPTS type messenger
    text with two alternatively spliced isoforms, acting as a muscle specific isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1061 - 215 - 2005 15784678
    11 - 3191 - 925 - 2005 15784678
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunetonsils   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal specific Homo sapiens
    Muscularstriatumcardiac specific Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text bone development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a NAC domain, with a region as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • transcriptional coactivator, preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic
  • reticulum (ER)
  • cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line
  • is a new factor involved in the positive regulation of human erythroid-cell differentiation
  • may act as a specific coactivator for JUN, binding to DNA
  • and stabilizing the interaction of JUN homodimers with target gene promoters
  • participates in the proper maturation of newly synthesized proteins
  • its degradation triggers ER stress responses and initiates apoptotic processes in hypoxic cells, and GSK3B may participate upstream in this mechanism
  • plays potentially a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration
  • plays a role in regulating gene transcription during mesenchymal cell differentiation by differentially recruiting corepressors at target promoters
  • controls myoblast migration and sarcomere architecture in a calpain-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with newly synthesized polypeptide chains
  • heterodimer, and its two subunits form a stable complex through a dimerizing domain called the NAC domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TBP and JUN
  • NACA may serve as an intracellular regulator of FADD function
  • is the major binding partner for SMYD1 in the developing heart
  • functional interaction between ATF4, TXLNG, and NACA, three proteins that have been previously shown to associate using various protein-protein interaction assays
  • acts as a transcriptional coactivator of the Osteocalcin gene
  • inhibition of NACA gene expression leads to enhanced, and overexpression of NACA gene to repressed, activity of CAPN1 and, to a lesser extent, CAPN3 in myoblasts
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • viable skNAC(-/-) adult mice had reduced postnatal skeletal muscle growth and impaired regenerative capacity after cardiotoxin-induced injury