Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NACA contributors: mct - updated : 10-12-2012
HGNC name nascent-polypeptide-associated complex alpha polypeptide
HGNC id 7629
Location 12q13.3      Physical location : 57.106.210 - 57.119.326
Synonym name
  • NAC-alpha
  • skeletal and heart muscle specific variant of nascent polypeptide-associated complex alpha
  • Synonym symbol(s) HSD48, skNAC, NACA1
    EC.number 5.3.99.3
    DNA
    TYPE functioning gene
    STRUCTURE 13.12 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text with two alternatively spliced isoforms, acting as a muscle specific isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1061 - 215 - 2005 15784678
    11 - 3191 - 925 - 2005 15784678
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunetonsils   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal specific Homo sapiens
    Muscularstriatumcardiac specific Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text bone development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a NAC domain, with a region as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • transcriptional coactivator, preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic
  • reticulum (ER)
  • cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line
  • is a new factor involved in the positive regulation of human erythroid-cell differentiation
  • may act as a specific coactivator for JUN, binding to DNA
  • and stabilizing the interaction of JUN homodimers with target gene promoters
  • participates in the proper maturation of newly synthesized proteins
  • its degradation triggers ER stress responses and initiates apoptotic processes in hypoxic cells, and GSK3B may participate upstream in this mechanism
  • plays potentially a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration
  • plays a role in regulating gene transcription during mesenchymal cell differentiation by differentially recruiting corepressors at target promoters
  • controls myoblast migration and sarcomere architecture in a calpain-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with newly synthesized polypeptide chains
  • heterodimer, and its two subunits form a stable complex through a dimerizing domain called the NAC domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TBP and JUN
  • NACA may serve as an intracellular regulator of FADD function
  • is the major binding partner for SMYD1 in the developing heart
  • functional interaction between ATF4, TXLNG, and NACA, three proteins that have been previously shown to associate using various protein-protein interaction assays
  • acts as a transcriptional coactivator of the Osteocalcin gene
  • inhibition of NACA gene expression leads to enhanced, and overexpression of NACA gene to repressed, activity of CAPN1 and, to a lesser extent, CAPN3 in myoblasts
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • viable skNAC(-/-) adult mice had reduced postnatal skeletal muscle growth and impaired regenerative capacity after cardiotoxin-induced injury