basic FUNCTION
| playing an essential role for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage |
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influencing diverse endpoints in the cellular DNA damage response |
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plays a key role in DNA damage response |
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promotes Rad51-mediated strand exchange and may thus contribute directly to homologous recombination repair |
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may also be involved in preventing tumorigenesis and might affect the response of patients and tumours towards radiotherapy and DNA-damaging chemotherapies |
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participating in homologous recombination (HR)-dependent repair of DNA double strand breaks and ATM-mediated checkpoint pathways |
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SOSS complex (NABP1, NABP2, INTS3, INIP) is likely involved in the maintenance of genome stability |
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plays an important role in the DNA damage response and maintenance of genomic stability |
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essential for efficient DNA double-strand break signalling through ATM |
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functions upstream of MRN complex ((RAD50, MRE11, NBS1))to promote its recruitment at DSBs (double-strand break) and is required for efficient resection of DSBs |
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essential roles in controlling ATM activation and activity, and subsequent DSB resection and homologous recombination (HR) |
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essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic stabilityc |
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has a unique function during embryogenesis limited to cell types that contribute to bone formation |
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critical for the initiation of ATM signaling and DNA double-strand break repair by homologous recombination |
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essential roles in embryogenesis, spermatogenesis, and genome stability |
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potential role for NABP2/NABP1 in the protection of newly replicated leading- and lagging-strand telomeres |
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importance of NABP2 in maintaining and repairing DNA replication forks and for overall genomic stability |
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participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling |
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NABP1 and 2 are single-stranded (ss) DNA- and RNA-binding proteins, and function in DNA repair |
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