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FLASH GENE
Symbol NAB1 contributors: - updated : 05-09-2005
HGNC name NGFI-A binding protein 1 (EGR1 binding protein 1)
HGNC id 7626
Location 2q32.3-q33      Physical location : 191.513.847 - 191.557.491
Synonym name NGFI-A (nerve growth factor induced clone A) binding protein 1
DNA
TYPE functioning gene
STRUCTURE 33.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivestomach   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NAB conserved domain 2 (NCD2)
  • a nuclear localization signal (NLS), in the carboxy terminal region for repressible function
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • repressor of EGR2 and EGR1
  • transcriptional repressor acting as an endogenous regulator of cardiac growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex NAB1/EGR1 crucial regulator of pathological cardiac growth
  • INTERACTION
    DNA
    RNA
    small molecule
    protein EGR2 and EGR1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS