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FLASH GENE
Symbol NAALAD2 contributors: mct - updated : 19-02-2018
HGNC name N-acetylated alpha-linked acidic dipeptidase 2
HGNC id 14526
Location 11q14.3      Physical location : 89.867.817 - 89.925.770
Synonym name
  • NAALADase II
  • glutamate carboxypeptidase III
    • Synonym symbol(s) NAADALASE2, NAALADASE2, MGC26353, MGC116996, GCPIII, GPCIII
    EC.number 3.4.17.21
    DNA
    TYPE functioning gene
    STRUCTURE 61.88 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3097 - 707 - 1999 10085079
    19 - 3196 - 740 - 1999 10085079
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  predominantly
    Hearing/Equilibriumear   highly
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis  highly
     male systemprostate  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text moderately in embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal transmembrane domain
  • a central region involved in the NAALADase activity
  • the dipeptidyl peptidase IV type activity in the C-terminal region
  • seven potential N-glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Naalad2 (88.4 pc)
    homolog to murine Naalad2 (88.1 pc)
    Homologene
    FAMILY
  • peptidase M28 family
  • M28B subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type II membrane protein
    basic FUNCTION
  • having N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity
  • also exhibiting a dipeptidyl-peptidase IV type activity
  • inactivating the peptide neurotransmitter N-acetylaspartylglutamate
  • acting as a metallopeptidase
  • playing a role of serine-type peptidase
  • forms likely a labile catalytic Zn-Ca cluster that is critical for its beta-citrylglutamate hydrolase activity
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+ (binding 2 ions per subunit)
    • protein
    cell & other
    REGULATION
    inhibited by quisqualate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS