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FLASH GENE
Symbol NAA35 contributors: mct/npt - updated : 17-12-2018
HGNC name N(alpha)-acetyltransferase 35, NatC auxiliary subunit
HGNC id 24340
Location 9q21.33      Physical location : 88.556.056 - 88.637.216
Synonym name
  • embryonic growth-associated protein homolog
  • corneal wound healing-related protein
  • MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae)
  • Synonym symbol(s) FLJ21613, FLJ22643, bA379P1.1, EGAP, MAK10, MAK10P, T4a
    DNA
    TYPE functioning gene
    STRUCTURE 85.21 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 2657 83.1 725 - 2000 10855038
    23 - 2649 83.1 725 - 2000 10855038
    23 - 6031 83.1 725 - 2000 10855038
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin     Rattus norvegicus
    Visualeyeanterior segmentcornea   Rattus norvegicus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis   Mus musculus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • MAK10 family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • potential role for this gene in epithelial development, differentiation
  • essential regulatory enzyme controlling the function of a subset of proteins required for embryonic growth control and vessel development (Wenzlau 2006)
  • NATc-mediated N-terminal acetylation is important for maintenance of protein function and cell viability in human cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of NATc complex with NAA30 and NAA38
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS