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FLASH GENE
Symbol NAA20 contributors: mct - updated : 16-03-2015
HGNC name N(alpha)-acetyltransferase 20, NatB catalytic subunit
HGNC id 15908
Location 20p11.22      Physical location : 19.997.936 - 20.014.268
Synonym name
  • N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
  • N-acetyltransferase 5, ARD1 subunit (arrest-defective 1, S. cerevisiae, homolog)
  • N-acetyltransferase 5", "N-acetyltransferase 5 (GCN5-related, putative)
  • Synonym symbol(s) NAT5, dJ1002M8.1, NAT3
    EC.number 2.3.1.88
    DNA
    TYPE functioning gene
    STRUCTURE 16.33 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1079 20.4 178 - -
    6 - 1065 - 166 - -
    5 - 933 - 111 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG7187
    Homologene
    FAMILY
  • Nat family protein
  • ARD1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • NAA20 and NAA25 forming a a complex important for cell-cycle progression
  • NAA25/NAA20 complex-mediated acetylation may play a role in the proliferation and differentiation of neural progenitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is only a known member of Nat family protein that interacts with NAA25
  • NAA25 directly associates with NAA20, but the overall cellular localization of the two proteins was slightly distinct, and NAA25 apparently co-localized with the polyQ aggregates
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS