Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NAA15 contributors: mct - updated : 12-06-2018
HGNC name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
HGNC id 30782
Corresponding disease
MRD50 mental retardation, autosomal dominant 50
Location 4q31.1      Physical location : 140.222.675 - 140.311.935
Synonym name
  • transcriptional coactivator tubedown-100
  • gastric cancer antigen Ga19
  • putative N-acetyltransferase
  • NMDA receptor regulated 1
  • tubedown-1
  • Synonym symbol(s) Ga19, NATH, FLJ13340, NAT1, TBDN100, NAT1P, TBDN, NARG1
    DNA
    TYPE functioning gene
    STRUCTURE 89.31 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 5609 105 866 - 2013 23557624
    TBDN100 V1
    - splicing 5566 - 526 - 2013 23557624
    an alternate splice site and so lacks 10 nt as compared to variant 1.
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Digestiveintestinesmall intestine   
    Nervousbrain     Homo sapiensFetal
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines Burkitt lymphoma cell line
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four tetratricopeptide repeat domains in 2 tandems and
  • a putative bipartite nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to murine Narg1
    ortholog to rattus narg1_predicted
    ortholog to chicken narg1
    Homologene
    FAMILY Nat1 family of proteins
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • NAA10 and NAA15 are both highly expressed in regions of cell division and migration during brain development
  • basic FUNCTION
  • acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development
  • having a function in the progression of papillary thyroid carcinomas
  • functional role for NAA15 in blood-vessel permeability dynamics that are crucial for vascular homeostasis
  • is an important regulator of retinal endothelial permeability and homeostasis by modulating a signaling pathway involving SRC and Cortactin
  • NAA15, a subunit of the N-terminal acetyltransferase NatA, complexes with the SRC substrate CTTN and supports adult retinal homeostasis through regulation of vascular permeability
  • role for NAA15 in development of the nervous system
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component non-catalytic component of the NATA N-terminal acetyltransferase, which is composed of ARD1A, NAT1 and NAT5 and catalyzing acetylation of proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NAA10 (NAA15 and NAA10 are cleaved during apoptosis, resulting in a decreased NAT activity)
  • associates with the acetyltransferase NAA10 and exerts an angiostatic function in adult retinal-blood-vessel homeostasis
  • association between NAA15 and CTTN, and NAA15 is involved in the regulation of retinal-endothelial-cell permeability to albumin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD50
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in papillary thyroid carcinomas
    constitutional     --low  
    decrease in the level of expression of NAA15 in the retinal and choroidal vasculature during aging contributes to the multifactorial process that leads to the development of age-related retinopathy and choroidopathy
    constitutional       loss of function
    of retinal endothelial NAA15 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity (ROP)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in mice, upregulated expression of Naa15 has been shown in regions of neuronal migration, and proliferation in the neonatal mouse brain has been shown along with reduced expression as neurons differentiate during early postnatal development