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Symbol N4BP2L2 contributors: mct - updated : 27-11-2009
HGNC name NEDD4 binding protein 2-like 2
HGNC id 26916
Location 13q13.1      Physical location : 33.006.929 - 33.112.936
Synonym name
  • phosphonoformate immuno-associated protein 5
  • protein from BCRA2 region
  • 92M18.3 (novel protein)
  • Synonym symbol(s) 92M18.3, CG005, FLJ36195, FLJ41089, FLJ43077, PFAAP5, CG016
    DNA
    TYPE functioning gene
    STRUCTURE 106.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2860 - 583 - 2008 19506020
    10 - 2482 - 752 - 2009 19506020
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text is also located in the nucleus
    basic FUNCTION
  • mediates neutrophil elastase and GFI1 transcriptional repressor cooperation
  • may have a role in promoting the maturation of the C-terminus of neutrophil elastase
  • required for neutrophil elastase transcriptional activity prior to the removal of the C-terminus and only once the propeptide is removed does neutrophil elastase become transcriptionally active
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ELA2 and GFI1 (mediating transcriptional repressor cooperation between GFI1 and Neutrophil Elastase)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS