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FLASH GENE
Symbol N4BP2 contributors: - updated : 15-04-2005
Location 4p14      Physical location : 40.058.523 - 40.157.017
Genatlas name Nedd4 binding protein 2
Synonym name BCL-3 binding protein
Synonym symbol(s) B3BP, FLJ10680, KIAA1413
DNA
TYPE functioning gene
STRUCTURE 59.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ11017 4p14 hypothetical protein FLJ11017 PGM2 4p14-q12 phosphoglucomutase 2 PTTG2 4p12 pituitary tumor-transforming 2 LOC338096 4p14 proteasome activator subunit 2 pseudogene MRPS33P2 4p14 mitochondrial ribosomal protein S33 pseudogene 2 TBC1D1 4p14 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 FLJ13197 4p14 hypothetical protein FLJ13197 KLF3 4p14 Kruppel-like factor 3 (basic) TLR10 4p14 toll-like receptor 10 TLR1 4p14 toll-like receptor 1 TLR6 4p16.1 toll-like receptor 6 LOC92689 4p14 hypothetical protein BC001096 FLJ23235 4p14 hypothetical protein FLJ23235 KLHL5 4p15.1-p13 kelch-like 5 (Drosophila) PWDMP 4p14 WD repeat membrane protein PWDMP RFC1 4p14-p13 replication factor C (activator 1) 1, 145kDa LOC152831 4p14 klotho beta like RPL9 4p13 ribosomal protein L9 LIAS 4p14 lipoic acid synthetase LOC391645 4 similar to WD repeat domain 5; Bmp2-induced gene UGDH 4p15.1 UDP-glucose dehydrogenase LOC201895 4p14 hypothetical protein LOC201895 HIP2 4p14 huntingtin interacting protein 2 LOC391646 4 similar to chromosome 6 open reading frame 46; Em:AF134726.1 KIAA0648 4p15.1-p11 similar to chromosome 6 open reading frame 46; Em:AF134726.1 PABPCP1 4p14 poly(A) binding protein, cytoplasmic, pseudogene 1 LOC391647 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC344967 4p14 similar to cytosolic acyl coenzyme A thioester hydrolase N4BP2 4p14 Nedd4 binding protein 2 ARHH 4p13 ras homolog gene family, member H LOC339997 4p14 hypothetical LOC339997 CHRNA9 4p15.1-p14 cholinergic receptor, nicotinic, alpha polypeptide 9 FLJ20273 4p13-p12 RNA-binding protein FLJ14001 4p14 hypothetical protein FLJ14001 APBB2 4p15.1-p14 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) UCHL1 4p15.1-p14 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) KIAA1102 4p13-p11 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) PHOX2B 4p12 paired-like homeobox 2b FLJ10525 4p14 hypothetical protein FLJ10525 LOC285429 4p14 hypothetical protein LOC285429 SLC30A9 4p13-p12 solute carrier family 30 (zinc transporter), member 9 ATP1BL1 4p15-q13 ATPase, Na+/K+ transporting, beta polypeptide-like 1 LOC389206 4 hypothetical gene supported by AK125953 ATP8A1 4p14-p12 ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a polynucleotide kinase domain (PNK) near the N-terminal region
  • N-terminal region containing the ATP-binding site important for the interaction with BCL-3 and p300/CBP
  • a small MutS Related (Smr) domain near the C-terminal region, involved in the DNA repair or recombination reaction
  • conjugated Other
    HOMOLOGY
    interspecies ortholog to murine B3bp
    Homologene
    FAMILY
    CATEGORY enzyme , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having 5'-polynucleotide kinase and nicking endonuclease activity
  • may play a role in transcription-coupled DNA repair or genetic recombination
  • playing a critical role in the development of a normal immune response and the formation of germinal centers in secondary lymphoid organs
  • CELLULAR PROCESS nucleotide, recombination
    nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitinated
  • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • NEDD4
  • interacting specifically with the bcl-3 gene product (BCL3)
  • CREBBP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS