Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol N4BP1 contributors: mct/npt - updated : 21-08-2007
HGNC name NEDD4 binding protein 1
HGNC id 29850
Location 16q12.1      Physical location : 48.572.638 - 48.644.120
Synonym name cDNA sequence,expressed in brain,>100kDa,related to KIAA0323
Synonym symbol(s) KIAA0615, FLJ31821, MGC176730
DNA
TYPE functioning gene
STRUCTURE 71.48 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388271 16q11.2 similar to RAB41 VPS35 16q13-q21 vacuolar protein sorting 35 (yeast) ORC6L 16q12 origin recognition complex, subunit 6 homolog-like (yeast) LOC91807 16q11.2 myosin light chain kinase (MLCK) LOC388272 16 similar to RIKEN cDNA 4921524J17 LOC124144 16q11.2 brain creatine kinase pseudogene GPT2 16q12.1 glutamic pyruvate transaminase (alanine aminotransferase) 2 DNAJA2 16q11.1-q11.2 DnaJ (Hsp40) homolog, subfamily A, member 2 NETO2 16q11.2 neuropilin (NRP) and tolloid (TLL)-like 2 LOC342451 16q11.2 similar to 60S ribosomal protein L23a CDA08 16q11.2 T-cell immunomodulatory protein PHKB 16q12.1 phosphorylase kinase, beta ABCC12 16q11-q12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 ABCC11 16q11-q12 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 LONP 16q12.1 peroxisomal lon protease SIAH1 16q12 seven in absentia homolog 1 (Drosophila) LOC255896 16q12.1 similar to molybdenum cofactor synthesis-step 1 protein isoform 2 FLJ31821 16q12.1 hypothetical protein FLJ31821 N4BP1 16q12.1 hypothetical protein FLJ31821 LOC388273 16 LOC388273 CBLN1 16q11.2-q12.2 cerebellin 1 precursor MGC33367 16q12.1 hypothetical protein MGC32905 OAZ 16q12 hypothetical protein MGC32905 ADAM3B 16q12.1 a disintegrin and metalloproteinase domain 3b (cyritestin 2) MRPS21P7 16q12.1 mitochondrial ribosomal protein S21 pseudogene 7 MRPS21P8 16q12.1 mitochondrial ribosomal protein S21 pseudogene 8 FLJ38101 16q12.1 hypothetical protein FLJ38101 FLJ20718 16q12.1 hypothetical protein FLJ20718 LOC390729 16 similar to 60S ribosomal protein L10 (QM protein homolog) TRF4-2 16q12.1 topoisomerase-related function protein 4-2 ADCY7 16q12-q13 adenylate cyclase 7 BRD7 16q12 bromodomain containing 7
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 7121 - 896 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to KIAA0323
Homologene
FAMILY
  • N4BP1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functions as a negative regulator of ITCH (inhibits its ubiquitylation activity)
  • may have a role in regulating tumor progression and the response of cancer cells to chemotherapy
  • polyubiquitin binding protein involved in NF-kappaB signaling (Fenner 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds NEDD4 (substrate of the homologous to E6AP C terminus (HECT) domain-containing E3 ubiquitin-protein ligase (E3), NEDD4)
  • functional interaction between N4BP1 and ITCH, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS