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FLASH GENE
Symbol MZT2B contributors: mct - updated : 11-01-2021
HGNC name mitotic spindle organizing protein 2B
HGNC id 25886
Location 2q21.1      Physical location : 130.939.500 - 130.948.299
Synonym name
  • mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B
  • hypothetical protein LOC80097
  • family with sequence similarity 128, member B
  • Synonym symbol(s) FLJ14346, MGC87017, MOZART2B, FAM128B
    DNA
    TYPE functioning gene
    STRUCTURE 8.47 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 765 - 158 - 2011 21399614
    4 - 779 - 218 - 2011 21399614
    2 - 450 - 130 - 2011 21399614
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
     salivary gland    
    Lymphoid/Immunelymph node    
     thymus    
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine 2410018G20Rik
    Homologene
    FAMILY
  • FAM128 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • mitotic spindle-organizing protein associated with a ring of gamma tubulin2B
  • MZT1, MZT2A, MZT2B copurified with subunits of the gamma-tubulin ring complex (gamma-TuRC), which is essential for spindle assembly and chromosome segregation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with early and advanced stages, lymph nodes, distant metastases and risk factors such as H. pylori in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS