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FLASH GENE
Symbol MZT1 contributors: mct - updated : 16-12-2016
HGNC name mitotic spindle organizing protein 1
HGNC id 33830
Location 13q22.1      Physical location : 73.282.494 - 73.301.938
Genatlas name mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1
Synonym name
  • hypothetical protein LOC440145
    • Synonym symbol(s) LOC440145, FLJ21869, MGC150539, RP11-11C5.2, C13orf37, MOZART1
    DNA
    TYPE functioning gene
    STRUCTURE 19.44 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2412 - 82 - 2013 24006493
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast Mzt1
    Homologene
    FAMILY
  • UPF0582 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • plays a unique role within the TUBG1 components in attachment of this complex to the major microtubule organizing centers (MTOCs) site
  • plays an essential role in mitotic spindle formation as a component of the Gamma-tubulin ring complex
  • MST1 contributes to the microtubule-organizing centers (MTOCs) function through regulation of TUBGCP3
  • MZT1 is a 'priming factor' for gamma-tubulin ring complex (GTuRC) that allows spatial regulation of nucleation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a direct interaction between recombinant MST1 and the N-terminal region of TUBGCP3
  • recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS