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FLASH GENE
Symbol MYT1 contributors: mct - updated : 14-05-2014
HGNC name myelin transcription factor 1
HGNC id 7622
Location 20q13.33      Physical location : 62.795.826 - 62.873.604
Synonym name
  • proteolipid protein-binding protein
  • neural zinc finger transcription factor 2
  • Synonym symbol(s) KIAA1050, PLPB1, KIAA0835, MTF1, C20orf36, ZC2HC4A, NZF2
    DNA
    TYPE functioning gene
    STRUCTURE 77.78 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    Map pter - D20S568E - ZBTB33 - SOX18 - NPBWR2 - MYT1 - D20S535E - qter
    Authors Ensemble (02), Deloukas (01)
    Physical map
    FLJ20825 20q13.33 hypothetical protein FLJ20825 C20orf135 20q13.33 chromosome 20 open reading frame 135 TPD52L2 20q13.2-q13.3 tumor protein D52-like 2 LOC388808 20 LOC388808 URKL1 20q13.33 uridine kinase-like 1 KIAA1196 20q13.33 KIAA1196 protein C20orf136 20q13.33 chromosome 20 open reading frame 136 C20orf14 20q13.33 chromosome 20 open reading frame 14 LOC284739 20q13.33 hypothetical protein LOC284739 SOX18 20q13.33 SRY (sex determining region Y)-box 18 TCEA2 20q13 transcription elongation factor A (SII), 2 RGS19 20q13.3 regulator of G-protein signalling 19 OPRL1 20p11.2 opiate receptor-like 1 LOC391262 20 similar to salivary proline-rich protein GPR8 20q13.3 G protein-coupled receptor 8 MYT1 20q13.33 myelin transcription factor 1 C20orf36 20q13.33 chromosome 20 open reading frame 36 LOC388809 20 similar to bA476I15.3 (novel protein similar to septin)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5550 - 1121 - 2007 14962745
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Endocrineneuroendocrinepituitary   
     pancreas    
     parathyroid    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Mus musculus
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    Nervousneuron Mus musculus
    cell lineage neural and oligodendrocyte progenitor cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text developing nervous system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven zinc fingers (ZFs) motifs of the C2HC class arranged in two widely separated clusters, and a two-ZF unit interacts with the major groove of the entire RARE motif and both fingers bind in an identical manner
  • four-zinc finger DNA-binding region (4FMyt1)
  • a central protein-protein interaction domain (CDMyt1)
  • HOMOLOGY
    interspecies homolog to murine Myt1
    intraspecies paralog to MYT1L
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) gene family
  • Myt/NZF family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator of PLP
  • binding to the promoter regions of proteolipid proteins of the central nervous system and playing a role in the development of neurons and oligodendrogalia in the CNS
  • may favor the silencing of genes during neural development
  • may regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription
  • having functions in checkpoint recovery and potentially is a target for anti-cancer therapies
  • transcription factor that plays a central role in the developing central nervous system
  • may have a regulatory function in a specific phase during neuronal differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text neurogenesis, development of nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the promoter of proteolipid proteins
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacted with SIN3B, a protein that mediates transcriptional repression by binding to histone deacetylases (HDACs)
  • both WEE1 and MYT1 can phosphorylate CDK1
  • cell & other
    REGULATION
    Phosphorylated by CDK1/XRINGO early during oocyte maturation that not only downregulates MYT1 kinase activity but also facilitates the recruitment of RPS6KA1 and further phosphorylation of MYT1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS